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Elevated C-reactive protein and self-reported disease activity in systemic lupus erythematosus.

Publication ,  Journal Article
Eudy, AM; Vines, AI; Dooley, MA; Cooper, GS; Parks, CG
Published in: Lupus
December 2014

C-reactive protein (CRP), a biomarker of inflammation, has been associated with increased disease activity in rheumatoid arthritis. However, the association in systemic lupus erythematosus (SLE) remains unclear. We examined the association of CRP with self-reported disease activity in the Carolina Lupus Study and described differences by sociodemographic characteristics. The study included baseline and three-year follow-up data on 107 African-American and 69 Caucasian SLE patients enrolled at a median 13 months since diagnosis. Models estimated prevalence differences in the association of baseline CRP with self-reported flares, adjusting for age, sex, race and education. Active disease or flare was reported by 59% at baseline and 58% at follow-up. Higher CRP (>10 µg/ml vs. <3 µg/ml) was associated with a 17% (95% confidence interval (CI): -20, 53%) higher prevalence of flare at baseline and a 26% (95% CI: -9, 62%) higher prevalence of flare at follow-up. These CRP-flare associations were notably stronger in patients with lower education at baseline and in African-Americans at follow-up. These findings suggest that CRP may be a useful marker in studies of SLE health disparities.

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Published In

Lupus

DOI

EISSN

1477-0962

Publication Date

December 2014

Volume

23

Issue

14

Start / End Page

1460 / 1467

Location

England

Related Subject Headings

  • Young Adult
  • White People
  • Severity of Illness Index
  • Self Report
  • Middle Aged
  • Male
  • Lupus Erythematosus, Systemic
  • Humans
  • Follow-Up Studies
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Eudy, A. M., Vines, A. I., Dooley, M. A., Cooper, G. S., & Parks, C. G. (2014). Elevated C-reactive protein and self-reported disease activity in systemic lupus erythematosus. Lupus, 23(14), 1460–1467. https://doi.org/10.1177/0961203314543915
Eudy, A. M., A. I. Vines, M. A. Dooley, G. S. Cooper, and C. G. Parks. “Elevated C-reactive protein and self-reported disease activity in systemic lupus erythematosus.Lupus 23, no. 14 (December 2014): 1460–67. https://doi.org/10.1177/0961203314543915.
Eudy AM, Vines AI, Dooley MA, Cooper GS, Parks CG. Elevated C-reactive protein and self-reported disease activity in systemic lupus erythematosus. Lupus. 2014 Dec;23(14):1460–7.
Eudy, A. M., et al. “Elevated C-reactive protein and self-reported disease activity in systemic lupus erythematosus.Lupus, vol. 23, no. 14, Dec. 2014, pp. 1460–67. Pubmed, doi:10.1177/0961203314543915.
Eudy AM, Vines AI, Dooley MA, Cooper GS, Parks CG. Elevated C-reactive protein and self-reported disease activity in systemic lupus erythematosus. Lupus. 2014 Dec;23(14):1460–1467.
Journal cover image

Published In

Lupus

DOI

EISSN

1477-0962

Publication Date

December 2014

Volume

23

Issue

14

Start / End Page

1460 / 1467

Location

England

Related Subject Headings

  • Young Adult
  • White People
  • Severity of Illness Index
  • Self Report
  • Middle Aged
  • Male
  • Lupus Erythematosus, Systemic
  • Humans
  • Follow-Up Studies
  • Female