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Bcl-2 accelerates multistep prostate carcinogenesis in vivo.

Publication ,  Journal Article
Bruckheimer, EM; Brisbay, S; Johnson, DJ; Gingrich, JR; Greenberg, N; McDonnell, TJ
Published in: Oncogene
November 2, 2000

The impact of bcl-2 proto-oncogene expression on the pathogenesis and progression of prostate cancer was examined in a transgenic mouse model. Probasin-bcl-2 transgenic mice were crossed with TRAMP (TRansgenic Adenocarcinoma Mouse Prostate) mice that express the SV40 early genes (T/t antigens) under probasin control. Prostate size, cell proliferation, apoptosis, and the incidence and latency of tumor formation were evaluated. The double transgenic, probasin-bcl-2 X TRAMP F1 (BxT) mice exhibited an increase in the wet weight of the prostate. This was associated with an increase in proliferation, attributable to T/t antigens, and a decrease in apoptosis attributable to bcl-2. The latency to tumor formation was also decreased in the BxT mice compared to the TRAMP mice. The incidence of metastases was identical in both the TRAMP and BxT mice. Lastly, the incidence of hormone-independent prostate cancer was reduced in the BxT mice compared to the TRAMP mice. Together, these results demonstrate that bcl-2 can facilitate multistep prostate carcinogenesis in vivo.

Duke Scholars

Published In

Oncogene

DOI

ISSN

0950-9232

Publication Date

November 2, 2000

Volume

19

Issue

46

Start / End Page

5251 / 5258

Location

England

Related Subject Headings

  • Transgenes
  • Time Factors
  • Proto-Oncogene Proteins c-bcl-2
  • Prostatic Neoplasms
  • Organ Size
  • Oncology & Carcinogenesis
  • Neoplasm Metastasis
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Mice
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bruckheimer, E. M., Brisbay, S., Johnson, D. J., Gingrich, J. R., Greenberg, N., & McDonnell, T. J. (2000). Bcl-2 accelerates multistep prostate carcinogenesis in vivo. Oncogene, 19(46), 5251–5258. https://doi.org/10.1038/sj.onc.1203881
Bruckheimer, E. M., S. Brisbay, D. J. Johnson, J. R. Gingrich, N. Greenberg, and T. J. McDonnell. “Bcl-2 accelerates multistep prostate carcinogenesis in vivo.Oncogene 19, no. 46 (November 2, 2000): 5251–58. https://doi.org/10.1038/sj.onc.1203881.
Bruckheimer EM, Brisbay S, Johnson DJ, Gingrich JR, Greenberg N, McDonnell TJ. Bcl-2 accelerates multistep prostate carcinogenesis in vivo. Oncogene. 2000 Nov 2;19(46):5251–8.
Bruckheimer, E. M., et al. “Bcl-2 accelerates multistep prostate carcinogenesis in vivo.Oncogene, vol. 19, no. 46, Nov. 2000, pp. 5251–58. Pubmed, doi:10.1038/sj.onc.1203881.
Bruckheimer EM, Brisbay S, Johnson DJ, Gingrich JR, Greenberg N, McDonnell TJ. Bcl-2 accelerates multistep prostate carcinogenesis in vivo. Oncogene. 2000 Nov 2;19(46):5251–5258.

Published In

Oncogene

DOI

ISSN

0950-9232

Publication Date

November 2, 2000

Volume

19

Issue

46

Start / End Page

5251 / 5258

Location

England

Related Subject Headings

  • Transgenes
  • Time Factors
  • Proto-Oncogene Proteins c-bcl-2
  • Prostatic Neoplasms
  • Organ Size
  • Oncology & Carcinogenesis
  • Neoplasm Metastasis
  • Mice, Transgenic
  • Mice, Inbred C57BL
  • Mice