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Pregnancy with prolonged fetal exposure to an angiotensin-converting enzyme inhibitor.

Publication ,  Journal Article
Muller, PR; James, A
Published in: J Perinatol
2002

Maternal exposure to angiotensin-converting enzyme (ACE) inhibitors has consistently been associated with significant fetal toxicity. We report the case of a 24-year-old woman, gravida 3, para 1-0-1-1 who presented at 24 2/7 weeks' gestation with initial abnormal fetal sonographic findings, including severe oligohydramnios, misshapen cranium, pericardial effusion, small bladder, and echogenic bowel, all after prolonged exposure to multiple medications including an ACE inhibitor. Eighteen days after discontinuation of the ACE inhibitor, repeat fetal sonography revealed normal amniotic fluid and normal cranial and fetal anatomy. The patient gave birth to a normal infant at 36 weeks' gestation. Poor neonatal outcome with prolonged antenatal exposure to ACE inhibitors is not inevitable. Early follow up sonographic evaluation in patients with prolonged exposure to ACE inhibitors may allow physicians to more accurately counsel patients on pregnancy outcome.

Duke Scholars

Published In

J Perinatol

DOI

ISSN

0743-8346

Publication Date

2002

Volume

22

Issue

7

Start / End Page

582 / 584

Location

United States

Related Subject Headings

  • Ultrasonography, Prenatal
  • Skull
  • Pregnancy Outcome
  • Pregnancy
  • Pediatrics
  • Oligohydramnios
  • Maternal Exposure
  • Intestines
  • Hypertension
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Muller, P. R., & James, A. (2002). Pregnancy with prolonged fetal exposure to an angiotensin-converting enzyme inhibitor. J Perinatol, 22(7), 582–584. https://doi.org/10.1038/sj.jp.7210766
Muller, Peter R., and Andra James. “Pregnancy with prolonged fetal exposure to an angiotensin-converting enzyme inhibitor.J Perinatol 22, no. 7 (2002): 582–84. https://doi.org/10.1038/sj.jp.7210766.
Muller, Peter R., and Andra James. “Pregnancy with prolonged fetal exposure to an angiotensin-converting enzyme inhibitor.J Perinatol, vol. 22, no. 7, 2002, pp. 582–84. Pubmed, doi:10.1038/sj.jp.7210766.

Published In

J Perinatol

DOI

ISSN

0743-8346

Publication Date

2002

Volume

22

Issue

7

Start / End Page

582 / 584

Location

United States

Related Subject Headings

  • Ultrasonography, Prenatal
  • Skull
  • Pregnancy Outcome
  • Pregnancy
  • Pediatrics
  • Oligohydramnios
  • Maternal Exposure
  • Intestines
  • Hypertension
  • Humans