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A TGF-β1 genetic variant at the miRNA187 binding site significantly modifies risk of HPV16-associated oropharyngeal cancer.

Publication ,  Journal Article
Tao, Y; Sturgis, EM; Huang, Z; Sun, Y; Dahlstrom, KR; Wei, Q; Li, G
Published in: Int J Cancer
September 15, 2018

TGF-β1rs1982073 polymorphism at the miRNA-187 binding site may alter TGF-β1 expression and function, and thereby this polymorphism (genotype CT/CC) increases cancer susceptibility. HPV16 L1 seropositivity is associated with the risk of oral squamous cell carcinoma (OSCC), including oropharyngeal squamous cell carcinoma (OPSCC) and oral cavity squamous cell carcinoma (OCSCC). Thus, we hypothesized that TGF-β1rs1982073 polymorphism at the miRNA-187 binding site combined with HPV16 L1 seropositivity may have a joint effect on OSCC susceptibility. We determined the genotypes of TGF-β1rs1982073 and HPV16 status in 325 OSCC subjects and 335 cancer-free controls in the non-Hispanic white population, and used logistic regression models to evaluate the joint effects on OSCC susceptibility. TGF-β1rs1982073 polymorphism (CT/CC genotype) combined with HPV16 L1 seropositivity increased the risk of OSCC via joint effects, particularly in OPSCC subjects who were never-smokers (OR, 165.9; 95% CI, 28.6-960.4) or never-drinkers (OR, 196.0; 95% CI, 28.2-1,000.0), respectively. Younger subjects had a higher risk of OPSCC than older subjects (OR, 23.5; 95% CI, 6.3-87.0 vs. OR, 6.0; 95% CI, 1.7-17.9, respectively). The significant associations between this polymorphism and HPV16-associated OSCC and OPSCC were also observed. However, OCSCC subjects did not have similar results. Our findings suggest that the joint effects of TGF-β1rs1982073 and HPV16 L1 seropositivity can increase risk of HPV16-associated oral cancer, particularly in OPSCC subjects who are never-smokers, never-drinkers and young. This result may help us understand the tumorigenesis process and improve early detection, which are critical for prevention and intervention strategies. However, larger studies are needed to validate our findings.

Duke Scholars

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

September 15, 2018

Volume

143

Issue

6

Start / End Page

1327 / 1334

Location

United States

Related Subject Headings

  • Transforming Growth Factor beta1
  • Prognosis
  • Polymorphism, Single Nucleotide
  • Papillomavirus Infections
  • Oropharyngeal Neoplasms
  • Oncology & Carcinogenesis
  • Oncogene Proteins, Viral
  • Middle Aged
  • MicroRNAs
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Tao, Y., Sturgis, E. M., Huang, Z., Sun, Y., Dahlstrom, K. R., Wei, Q., & Li, G. (2018). A TGF-β1 genetic variant at the miRNA187 binding site significantly modifies risk of HPV16-associated oropharyngeal cancer. Int J Cancer, 143(6), 1327–1334. https://doi.org/10.1002/ijc.31530
Tao, Ye, Erich M. Sturgis, Zhigang Huang, Yan Sun, Kristina R. Dahlstrom, Qingyi Wei, and Guojun Li. “A TGF-β1 genetic variant at the miRNA187 binding site significantly modifies risk of HPV16-associated oropharyngeal cancer.Int J Cancer 143, no. 6 (September 15, 2018): 1327–34. https://doi.org/10.1002/ijc.31530.
Tao Y, Sturgis EM, Huang Z, Sun Y, Dahlstrom KR, Wei Q, et al. A TGF-β1 genetic variant at the miRNA187 binding site significantly modifies risk of HPV16-associated oropharyngeal cancer. Int J Cancer. 2018 Sep 15;143(6):1327–34.
Tao, Ye, et al. “A TGF-β1 genetic variant at the miRNA187 binding site significantly modifies risk of HPV16-associated oropharyngeal cancer.Int J Cancer, vol. 143, no. 6, Sept. 2018, pp. 1327–34. Pubmed, doi:10.1002/ijc.31530.
Tao Y, Sturgis EM, Huang Z, Sun Y, Dahlstrom KR, Wei Q, Li G. A TGF-β1 genetic variant at the miRNA187 binding site significantly modifies risk of HPV16-associated oropharyngeal cancer. Int J Cancer. 2018 Sep 15;143(6):1327–1334.
Journal cover image

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

September 15, 2018

Volume

143

Issue

6

Start / End Page

1327 / 1334

Location

United States

Related Subject Headings

  • Transforming Growth Factor beta1
  • Prognosis
  • Polymorphism, Single Nucleotide
  • Papillomavirus Infections
  • Oropharyngeal Neoplasms
  • Oncology & Carcinogenesis
  • Oncogene Proteins, Viral
  • Middle Aged
  • MicroRNAs
  • Male