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Sepsis-Induced Coagulopathy and Japanese Association for Acute Medicine DIC in Coagulopathic Patients with Decreased Antithrombin and Treated by Antithrombin.

Publication ,  Journal Article
Iba, T; Arakawa, M; Levy, JH; Yamakawa, K; Koami, H; Hifumi, T; Sato, K
Published in: Clin Appl Thromb Hemost
October 2018

Disseminated intravascular coagulation (DIC) in patients with sepsis represents a critical condition. Thus, a simple and rapid diagnosis is required. The purpose of this study was to compare the performances of a recently developed Sepsis-Induced Coagulopathy (SIC) with the Japanese Association for Acute Medicine (JAAM) DIC. Four hundred nine patients with sepsis having coagulopathy and antithrombin activity of less than 70% and treated with antithrombin were retrospectively analyzed, and the SIC and JAAM-DIC criteria on days 1 (before treatment), 2, 4, and 7 were compared. The prevalence of JAAM-DIC on day 1 was significantly higher than that of SIC (91.4% vs 81.8%, P = .003), but there were no differences on days 2, 4, and 7. The mortality rates in the SIC and JAAM-DIC groups were both 23.3%. The specificity to 28-day mortality on day 1 was higher in the SIC group (15.8% vs 9.2%, P = .013). There were no differences in sensitivity on days 1, 2, 4, and 7. Mortality was significantly different between SIC-positive and SIC-negative groups on days 2, 4, and 7 ( P < .01, respectively), while significant differences were seen between JAAM-DIC-positive and JAAM-DIC-negative groups only on days 4 and 7 ( P < .05, .01, respectively). In summary, the SIC characteristics were similar to the JAAM-DIC group, and the classifications were comparable in terms of mortality prediction. The SIC scoring system is simple, easy to use, and adaptable to the new sepsis definitions and offers an important approach to evaluating patients in emergency and critical care settings.

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Published In

Clin Appl Thromb Hemost

DOI

EISSN

1938-2723

Publication Date

October 2018

Volume

24

Issue

7

Start / End Page

1020 / 1026

Location

United States

Related Subject Headings

  • Sepsis
  • Male
  • Humans
  • Female
  • Disseminated Intravascular Coagulation
  • Cardiovascular System & Hematology
  • Blood Coagulation Disorders
  • Asian People
  • Antithrombins
  • Aged, 80 and over
 

Citation

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Iba, T., Arakawa, M., Levy, J. H., Yamakawa, K., Koami, H., Hifumi, T., & Sato, K. (2018). Sepsis-Induced Coagulopathy and Japanese Association for Acute Medicine DIC in Coagulopathic Patients with Decreased Antithrombin and Treated by Antithrombin. Clin Appl Thromb Hemost, 24(7), 1020–1026. https://doi.org/10.1177/1076029618770273
Iba, Toshiaki, Makoto Arakawa, Jerrold H. Levy, Kazuma Yamakawa, Hiroyuki Koami, Toru Hifumi, and Koichi Sato. “Sepsis-Induced Coagulopathy and Japanese Association for Acute Medicine DIC in Coagulopathic Patients with Decreased Antithrombin and Treated by Antithrombin.Clin Appl Thromb Hemost 24, no. 7 (October 2018): 1020–26. https://doi.org/10.1177/1076029618770273.
Iba T, Arakawa M, Levy JH, Yamakawa K, Koami H, Hifumi T, et al. Sepsis-Induced Coagulopathy and Japanese Association for Acute Medicine DIC in Coagulopathic Patients with Decreased Antithrombin and Treated by Antithrombin. Clin Appl Thromb Hemost. 2018 Oct;24(7):1020–6.
Iba, Toshiaki, et al. “Sepsis-Induced Coagulopathy and Japanese Association for Acute Medicine DIC in Coagulopathic Patients with Decreased Antithrombin and Treated by Antithrombin.Clin Appl Thromb Hemost, vol. 24, no. 7, Oct. 2018, pp. 1020–26. Pubmed, doi:10.1177/1076029618770273.
Iba T, Arakawa M, Levy JH, Yamakawa K, Koami H, Hifumi T, Sato K. Sepsis-Induced Coagulopathy and Japanese Association for Acute Medicine DIC in Coagulopathic Patients with Decreased Antithrombin and Treated by Antithrombin. Clin Appl Thromb Hemost. 2018 Oct;24(7):1020–1026.
Journal cover image

Published In

Clin Appl Thromb Hemost

DOI

EISSN

1938-2723

Publication Date

October 2018

Volume

24

Issue

7

Start / End Page

1020 / 1026

Location

United States

Related Subject Headings

  • Sepsis
  • Male
  • Humans
  • Female
  • Disseminated Intravascular Coagulation
  • Cardiovascular System & Hematology
  • Blood Coagulation Disorders
  • Asian People
  • Antithrombins
  • Aged, 80 and over