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Genome-wide association analysis identifies a meningioma risk locus at 11p15.5.

Publication ,  Journal Article
Claus, EB; Cornish, AJ; Broderick, P; Schildkraut, JM; Dobbins, SE; Holroyd, A; Calvocoressi, L; Lu, L; Hansen, HM; Smirnov, I; Walsh, KM ...
Published in: Neuro Oncol
October 9, 2018

BACKGROUND: Meningiomas are adult brain tumors originating in the meningeal coverings of the brain and spinal cord, with significant heritable basis. Genome-wide association studies (GWAS) have previously identified only a single risk locus for meningioma, at 10p12.31. METHODS: To identify a susceptibility locus for meningioma, we conducted a meta-analysis of 2 GWAS, imputed using a merged reference panel from the 1000 Genomes Project and UK10K data, with validation in 2 independent sample series totaling 2138 cases and 12081 controls. RESULTS: We identified a new susceptibility locus for meningioma at 11p15.5 (rs2686876, odds ratio = 1.44, P = 9.86 × 10-9). A number of genes localize to the region of linkage disequilibrium encompassing rs2686876, including RIC8A, which plays a central role in the development of neural crest-derived structures, such as the meninges. CONCLUSIONS: This finding advances our understanding of the genetic basis of meningioma development and provides additional support for a polygenic model of meningioma.

Duke Scholars

Published In

Neuro Oncol

DOI

EISSN

1523-5866

Publication Date

October 9, 2018

Volume

20

Issue

11

Start / End Page

1485 / 1493

Location

England

Related Subject Headings

  • Young Adult
  • Risk Factors
  • Prognosis
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Middle Aged
  • Meningioma
  • Meningeal Neoplasms
  • Male
  • Linkage Disequilibrium
 

Citation

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Claus, E. B., Cornish, A. J., Broderick, P., Schildkraut, J. M., Dobbins, S. E., Holroyd, A., … Wiemels, J. L. (2018). Genome-wide association analysis identifies a meningioma risk locus at 11p15.5. Neuro Oncol, 20(11), 1485–1493. https://doi.org/10.1093/neuonc/noy077
Journal cover image

Published In

Neuro Oncol

DOI

EISSN

1523-5866

Publication Date

October 9, 2018

Volume

20

Issue

11

Start / End Page

1485 / 1493

Location

England

Related Subject Headings

  • Young Adult
  • Risk Factors
  • Prognosis
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Middle Aged
  • Meningioma
  • Meningeal Neoplasms
  • Male
  • Linkage Disequilibrium