Genome-wide association analysis identifies a meningioma risk locus at 11p15.5.
BACKGROUND: Meningiomas are adult brain tumors originating in the meningeal coverings of the brain and spinal cord, with significant heritable basis. Genome-wide association studies (GWAS) have previously identified only a single risk locus for meningioma, at 10p12.31. METHODS: To identify a susceptibility locus for meningioma, we conducted a meta-analysis of 2 GWAS, imputed using a merged reference panel from the 1000 Genomes Project and UK10K data, with validation in 2 independent sample series totaling 2138 cases and 12081 controls. RESULTS: We identified a new susceptibility locus for meningioma at 11p15.5 (rs2686876, odds ratio = 1.44, P = 9.86 × 10-9). A number of genes localize to the region of linkage disequilibrium encompassing rs2686876, including RIC8A, which plays a central role in the development of neural crest-derived structures, such as the meninges. CONCLUSIONS: This finding advances our understanding of the genetic basis of meningioma development and provides additional support for a polygenic model of meningioma.
Duke Scholars
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- Young Adult
- Risk Factors
- Prognosis
- Polymorphism, Single Nucleotide
- Oncology & Carcinogenesis
- Middle Aged
- Meningioma
- Meningeal Neoplasms
- Male
- Linkage Disequilibrium
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Young Adult
- Risk Factors
- Prognosis
- Polymorphism, Single Nucleotide
- Oncology & Carcinogenesis
- Middle Aged
- Meningioma
- Meningeal Neoplasms
- Male
- Linkage Disequilibrium