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Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders.

Publication ,  Journal Article
Ahmed, AT; Frye, MA; Rush, AJ; Biernacka, JM; Craighead, WE; McDonald, WM; Bobo, WV; Riva-Posse, P; Tye, SJ; Mayberg, HS; Hall-Flavin, DK ...
Published in: J Affect Disord
October 1, 2018

BACKGROUND: Substantial research progress can be achieved if available clinical datasets can be mapped to the National Institute of Mental Health Research-Domain-Criteria (RDoC) constructs. This mapping would allow investigators to both explore more narrowly defined clinical phenotypes and the relationship of these phenotypes to biological markers and clinical outcomes approximating RDoC criteria. METHODS: Using expert review and consensus, we defined four major depression phenotypes based on specific RDoC constructs. Having matched these constructs to individual items from the Hamilton Depression Rating Scale and Quick Inventory of Depressive Symptomatology, we identified subjects meeting criteria for each of these phenotypes from two large clinical trials of patients treated for major depression. In a post hoc analysis, we evaluated the overall treatment response based on the phenotypes: Core Depression (CD), Anxiety (ANX), and Neurovegetative Symptoms of Melancholia (NVSM) and Atypical Depression (NVSAD). RESULTS: The phenotypes were prevalent (range 10.5-52.4%, 50% reduction range 51.9-82.9%) and tracked with overall treatment response. Although the CD phenotype was associated with lower rates of remission in both cohorts, this was mainly driven by baseline symptom severity. However, when controlling for baseline severity, patients with the ANX phenotype had a significantly lower rate of remission. LIMITATIONS: The lack of replication between the studies of the phenotypes' treatment prediction value reflects important variability across studies that may limit generalizability. CONCLUSION: Further work evaluating biological markers associated with these phenotypes is needed for further RDoC concept development.

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Published In

J Affect Disord

DOI

EISSN

1573-2517

Publication Date

October 1, 2018

Volume

238

Start / End Page

1 / 7

Location

Netherlands

Related Subject Headings

  • Research Design
  • Research
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Phenotype
  • Mood Disorders
  • Middle Aged
  • Male
  • Humans
  • Female
 

Citation

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Ahmed, A. T., Frye, M. A., Rush, A. J., Biernacka, J. M., Craighead, W. E., McDonald, W. M., … Mood Disorders Precision Medicine Consortium (MDPMC), . (2018). Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders. J Affect Disord, 238, 1–7. https://doi.org/10.1016/j.jad.2018.05.005
Ahmed, Ahmed T., Mark A. Frye, A John Rush, Joanna M. Biernacka, W Edward Craighead, William M. McDonald, William V. Bobo, et al. “Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders.J Affect Disord 238 (October 1, 2018): 1–7. https://doi.org/10.1016/j.jad.2018.05.005.
Ahmed AT, Frye MA, Rush AJ, Biernacka JM, Craighead WE, McDonald WM, et al. Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders. J Affect Disord. 2018 Oct 1;238:1–7.
Ahmed, Ahmed T., et al. “Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders.J Affect Disord, vol. 238, Oct. 2018, pp. 1–7. Pubmed, doi:10.1016/j.jad.2018.05.005.
Ahmed AT, Frye MA, Rush AJ, Biernacka JM, Craighead WE, McDonald WM, Bobo WV, Riva-Posse P, Tye SJ, Mayberg HS, Hall-Flavin DK, Skime MK, Jenkins GD, Wang L, Krishnan RR, Weinshilboum RM, Kaddurah-Daouk R, Dunlop BW, Mood Disorders Precision Medicine Consortium (MDPMC). Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders. J Affect Disord. 2018 Oct 1;238:1–7.
Journal cover image

Published In

J Affect Disord

DOI

EISSN

1573-2517

Publication Date

October 1, 2018

Volume

238

Start / End Page

1 / 7

Location

Netherlands

Related Subject Headings

  • Research Design
  • Research
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Phenotype
  • Mood Disorders
  • Middle Aged
  • Male
  • Humans
  • Female