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A proposed classification system for menstrual cycles in the menopause transition based on changes in serum hormone profiles.

Publication ,  Journal Article
Robertson, DM; Hale, GE; Fraser, IS; Hughes, CL; Burger, HG
Published in: Menopause
2008

OBJECTIVE: To characterize menstrual cycles in women in late reproductive age and the menopause transition, based on changes in serum hormone levels. DESIGN: Serum levels of estradiol, progesterone, follicle-stimulating hormone (FSH), luteinizing hormone, inhibin A, inhibin B, and antimüllerian hormone, as previously reported as mean data grouped according to the Stages of Reproductive Aging Workshop proposals, were analyzed in 55 women aged 45 to 55 and compared with those in 21 women aged 21 to 35. RESULTS: The ovulatory cycles in the older women were divided into three types. Type 1 cycles (n = 14, 33%) were those with hormone concentrations similar to the women aged 21 to 35 except for 20-fold lower antimüllerian hormone levels. Type 2 cycles (n = 24; 53%) had increased FSH, decreased inhibin B, and increased FSH-to-inhibin B ratios but normal estradiol and progesterone levels. Type 3 cycles had the same characteristics as type 2 cycles (n = 5; 12%) in addition to lower luteal phase progesterone and increased luteinizing hormone. CONCLUSIONS: The changes in hormone levels indicated in cycle types 1 to 3 closely reflect the changes in ovarian-pituitary activity as menopause approaches and are likely to be directly attributable to a decrease in ovarian follicle reserve. The findings suggest that FSH-to-inhibin B ratios and antimüllerian hormone are distinct early indicators of the menopause transition and are likely to be useful biomarkers of impending menopause. Furthermore, this classification may provide an improved basis for the study of reproductive endocrine disorders associated with the menopause transition.

Duke Scholars

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Published In

Menopause

DOI

EISSN

1530-0374

Publication Date

2008

Volume

15

Issue

6

Start / End Page

1139 / 1144

Location

United States

Related Subject Headings

  • Progesterone
  • Obstetrics & Reproductive Medicine
  • Middle Aged
  • Menopause
  • Luteinizing Hormone
  • Inhibins
  • Humans
  • Follicular Phase
  • Follicle Stimulating Hormone
  • Estradiol
 

Citation

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ICMJE
MLA
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Robertson, D. M., Hale, G. E., Fraser, I. S., Hughes, C. L., & Burger, H. G. (2008). A proposed classification system for menstrual cycles in the menopause transition based on changes in serum hormone profiles. Menopause, 15(6), 1139–1144. https://doi.org/10.1097/gme.0b013e3181735687
Robertson, David M., Georgina E. Hale, Ian S. Fraser, Claude L. Hughes, and Henry G. Burger. “A proposed classification system for menstrual cycles in the menopause transition based on changes in serum hormone profiles.Menopause 15, no. 6 (2008): 1139–44. https://doi.org/10.1097/gme.0b013e3181735687.
Robertson DM, Hale GE, Fraser IS, Hughes CL, Burger HG. A proposed classification system for menstrual cycles in the menopause transition based on changes in serum hormone profiles. Menopause. 2008;15(6):1139–44.
Robertson, David M., et al. “A proposed classification system for menstrual cycles in the menopause transition based on changes in serum hormone profiles.Menopause, vol. 15, no. 6, 2008, pp. 1139–44. Pubmed, doi:10.1097/gme.0b013e3181735687.
Robertson DM, Hale GE, Fraser IS, Hughes CL, Burger HG. A proposed classification system for menstrual cycles in the menopause transition based on changes in serum hormone profiles. Menopause. 2008;15(6):1139–1144.

Published In

Menopause

DOI

EISSN

1530-0374

Publication Date

2008

Volume

15

Issue

6

Start / End Page

1139 / 1144

Location

United States

Related Subject Headings

  • Progesterone
  • Obstetrics & Reproductive Medicine
  • Middle Aged
  • Menopause
  • Luteinizing Hormone
  • Inhibins
  • Humans
  • Follicular Phase
  • Follicle Stimulating Hormone
  • Estradiol