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A cellular Trojan Horse for delivery of therapeutic nanoparticles into tumors.

Publication ,  Journal Article
Choi, M-R; Stanton-Maxey, KJ; Stanley, JK; Levin, CS; Bardhan, R; Akin, D; Badve, S; Sturgis, J; Robinson, JP; Bashir, R; Halas, NJ; Clare, SE
Published in: Nano Lett
December 2007

Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as "Trojan Horses" for nanoparticle transport into these tumor regions. Here we report the demonstration of several key steps toward this therapeutic strategy: phagocytosis of Au nanoshells, and photoinduced cell death of monocytes/macrophages as isolates and within tumor spheroids.

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Published In

Nano Lett

DOI

ISSN

1530-6984

Publication Date

December 2007

Volume

7

Issue

12

Start / End Page

3759 / 3765

Location

United States

Related Subject Headings

  • Spectrophotometry
  • Neoplasms
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Monocytes
  • Macrophages
  • Humans
  • Drug Delivery Systems
  • Cell Hypoxia
  • Biological Transport
 

Citation

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Choi, M.-R., Stanton-Maxey, K. J., Stanley, J. K., Levin, C. S., Bardhan, R., Akin, D., … Clare, S. E. (2007). A cellular Trojan Horse for delivery of therapeutic nanoparticles into tumors. Nano Lett, 7(12), 3759–3765. https://doi.org/10.1021/nl072209h
Choi, Mi-Ran, Katie J. Stanton-Maxey, Jennifer K. Stanley, Carly S. Levin, Rizia Bardhan, Demir Akin, Sunil Badve, et al. “A cellular Trojan Horse for delivery of therapeutic nanoparticles into tumors.Nano Lett 7, no. 12 (December 2007): 3759–65. https://doi.org/10.1021/nl072209h.
Choi M-R, Stanton-Maxey KJ, Stanley JK, Levin CS, Bardhan R, Akin D, et al. A cellular Trojan Horse for delivery of therapeutic nanoparticles into tumors. Nano Lett. 2007 Dec;7(12):3759–65.
Choi, Mi-Ran, et al. “A cellular Trojan Horse for delivery of therapeutic nanoparticles into tumors.Nano Lett, vol. 7, no. 12, Dec. 2007, pp. 3759–65. Pubmed, doi:10.1021/nl072209h.
Choi M-R, Stanton-Maxey KJ, Stanley JK, Levin CS, Bardhan R, Akin D, Badve S, Sturgis J, Robinson JP, Bashir R, Halas NJ, Clare SE. A cellular Trojan Horse for delivery of therapeutic nanoparticles into tumors. Nano Lett. 2007 Dec;7(12):3759–3765.
Journal cover image

Published In

Nano Lett

DOI

ISSN

1530-6984

Publication Date

December 2007

Volume

7

Issue

12

Start / End Page

3759 / 3765

Location

United States

Related Subject Headings

  • Spectrophotometry
  • Neoplasms
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Monocytes
  • Macrophages
  • Humans
  • Drug Delivery Systems
  • Cell Hypoxia
  • Biological Transport