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Retinal Arteriolar Narrowing in Young Adults With Glaucomatous Optic Disc.

Publication ,  Journal Article
Adiarti, R; Ekantini, R; Agni, AN; Wong, TY; Sasongko, MB
Published in: J Glaucoma
August 2018

PURPOSE: Glaucomatous optic disc (GOD) might represent various subclinical processes. However, whether the presence of GOD is related to vascular processes is less clear. This study aimed to assess the retinal vessel diameter, as surrogate markers of vascular regulation, in healthy young adults with GOD compared with normal. MATERIALS AND METHODS: This was a clinic-based case-control study of 54 participants, aged between 18 and 30 years. We included patients with GOD (confirmed with slit-lamp and optical coherence tomography examination having cup-to-disc ratio ≥0.5), intraocular pressure ≤21 mm Hg, no history of hypertension, cardiovascular and kidney disease, anemia, diabetes mellitus, and spherical correction of ≤-1.5 D. Controls were healthy subjects with similar criteria but no sign of GOD. Retinal vessel diameters were measured using semiautomated program [Singapore I Vessel Assessment (SIVA) version 4.0] and expressed as central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent. RESULTS: The mean CRAE was significantly narrower in patients with GOD than controls (110.6±12.16 vs. 118.6±12.17; P=0.019). Central retinal venular equivalent was not significantly different. A CRAE narrower than 107.1 μm was significantly associated with GOD (odds ratio, 8.59; 95% confidence interval, 1.68-43.9; P<0.001) compared with controls. CONCLUSIONS: Retinal arterioles were narrower in young adults with GOD compared with normal, suggesting that the presence of GOD might be associated with subclinical changes in retinal vascularization even in the absence of increased intraocular pressure. However, the clinical significance of these findings deserves further studies.

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Published In

J Glaucoma

DOI

EISSN

1536-481X

Publication Date

August 2018

Volume

27

Issue

8

Start / End Page

699 / 702

Location

United States

Related Subject Headings

  • Young Adult
  • Tonometry, Ocular
  • Tomography, Optical Coherence
  • Slit Lamp Microscopy
  • Retinal Artery
  • Optic Nerve Diseases
  • Optic Disk
  • Ophthalmology & Optometry
  • Male
  • Intraocular Pressure
 

Citation

APA
Chicago
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MLA
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Adiarti, R., Ekantini, R., Agni, A. N., Wong, T. Y., & Sasongko, M. B. (2018). Retinal Arteriolar Narrowing in Young Adults With Glaucomatous Optic Disc. J Glaucoma, 27(8), 699–702. https://doi.org/10.1097/IJG.0000000000000997
Adiarti, Rossada, Retno Ekantini, Angela N. Agni, Tien Y. Wong, and Muhammad B. Sasongko. “Retinal Arteriolar Narrowing in Young Adults With Glaucomatous Optic Disc.J Glaucoma 27, no. 8 (August 2018): 699–702. https://doi.org/10.1097/IJG.0000000000000997.
Adiarti R, Ekantini R, Agni AN, Wong TY, Sasongko MB. Retinal Arteriolar Narrowing in Young Adults With Glaucomatous Optic Disc. J Glaucoma. 2018 Aug;27(8):699–702.
Adiarti, Rossada, et al. “Retinal Arteriolar Narrowing in Young Adults With Glaucomatous Optic Disc.J Glaucoma, vol. 27, no. 8, Aug. 2018, pp. 699–702. Pubmed, doi:10.1097/IJG.0000000000000997.
Adiarti R, Ekantini R, Agni AN, Wong TY, Sasongko MB. Retinal Arteriolar Narrowing in Young Adults With Glaucomatous Optic Disc. J Glaucoma. 2018 Aug;27(8):699–702.

Published In

J Glaucoma

DOI

EISSN

1536-481X

Publication Date

August 2018

Volume

27

Issue

8

Start / End Page

699 / 702

Location

United States

Related Subject Headings

  • Young Adult
  • Tonometry, Ocular
  • Tomography, Optical Coherence
  • Slit Lamp Microscopy
  • Retinal Artery
  • Optic Nerve Diseases
  • Optic Disk
  • Ophthalmology & Optometry
  • Male
  • Intraocular Pressure