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Associations Between Catecholaminergic and Serotonergic Genes and Persistent Breast Pain Phenotypes After Breast Cancer Surgery.

Publication ,  Journal Article
Knisely, MR; Conley, YP; Kober, KM; Smoot, B; Paul, SM; Levine, JD; Miaskowski, C
Published in: The journal of pain
October 2018

Genetic variations in the catecholaminergic and serotonergic pathways may contribute to the development and severity of persistent breast pain. However, investigations of these associations are limited. The purpose of this study was to evaluate for associations between breast pain phenotypes and single nucleotide polymorphisms among 15 genes involved in catecholaminergic and serotonergic neurotransmission. Women rated the presence and intensity of breast pain monthly for 6 months after breast cancer surgery. Distinct latent classes of patients were identified using growth mixture modeling. Logistic regression analyses identified significant differences between genotype or haplotype frequencies and the breast pain classes (ie, no breast pain [n = 96] vs mild breast pain [n = 141], moderate breast pain [n = 46], and severe breast pain [n = 27]). Polymorphisms in 5 genes were associated with membership in the mild pain class: ** beta-2-adrenergic receptor (ADRB2) rs2400707, beta adrenergic receptor kinase 2 (ADRBK2) HapA04, 5-hydroxytryptamine receptor 3A (HTR3A) rs10160548, solute-like carrier (SLC) family 6 member 2-noradrenaline transporter (SLC6A2) rs1566652, and tryptophan hydroxylase 2 (TPH2) rs11179000. Polymorphisms in 3 genes were associated with membership in the moderate pain class: 5-hydroxytryptamine receptor 2A (HTR2A) rs2296972, SLC6A2 rs17841327, and SLC6A3 rs403636. Polymorphisms in 3 genes were associated with membership in the severe pain class: COMT HPS haplotype, SLC family 6 member 2-noradrenaline transporter (SLC6A2) HapD01, and SLC family 6 member 3-noradrenaline transporter (SLC6A3) rs464049. The identification of these associations suggest possible underlying mechanisms that play a role in the development and severity of persistent breast pain.Findings from this study of women with breast cancer suggest that a number of catecholaminergic and serotonergic mechanisms may play a role in the development and severity of persistent breast pain phenotypes after surgery.

Duke Scholars

Published In

The journal of pain

DOI

EISSN

1528-8447

ISSN

1526-5900

Publication Date

October 2018

Volume

19

Issue

10

Start / End Page

1130 / 1146

Related Subject Headings

  • Synaptic Transmission
  • Serotonin
  • Prospective Studies
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Pain, Postoperative
  • Middle Aged
  • Longitudinal Studies
  • Humans
  • Genotype
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Knisely, M. R., Conley, Y. P., Kober, K. M., Smoot, B., Paul, S. M., Levine, J. D., & Miaskowski, C. (2018). Associations Between Catecholaminergic and Serotonergic Genes and Persistent Breast Pain Phenotypes After Breast Cancer Surgery. The Journal of Pain, 19(10), 1130–1146. https://doi.org/10.1016/j.jpain.2018.04.007
Knisely, Mitchell R., Yvette P. Conley, Kord M. Kober, Betty Smoot, Steven M. Paul, Jon D. Levine, and Christine Miaskowski. “Associations Between Catecholaminergic and Serotonergic Genes and Persistent Breast Pain Phenotypes After Breast Cancer Surgery.The Journal of Pain 19, no. 10 (October 2018): 1130–46. https://doi.org/10.1016/j.jpain.2018.04.007.
Knisely MR, Conley YP, Kober KM, Smoot B, Paul SM, Levine JD, et al. Associations Between Catecholaminergic and Serotonergic Genes and Persistent Breast Pain Phenotypes After Breast Cancer Surgery. The journal of pain. 2018 Oct;19(10):1130–46.
Knisely, Mitchell R., et al. “Associations Between Catecholaminergic and Serotonergic Genes and Persistent Breast Pain Phenotypes After Breast Cancer Surgery.The Journal of Pain, vol. 19, no. 10, Oct. 2018, pp. 1130–46. Epmc, doi:10.1016/j.jpain.2018.04.007.
Knisely MR, Conley YP, Kober KM, Smoot B, Paul SM, Levine JD, Miaskowski C. Associations Between Catecholaminergic and Serotonergic Genes and Persistent Breast Pain Phenotypes After Breast Cancer Surgery. The journal of pain. 2018 Oct;19(10):1130–1146.

Published In

The journal of pain

DOI

EISSN

1528-8447

ISSN

1526-5900

Publication Date

October 2018

Volume

19

Issue

10

Start / End Page

1130 / 1146

Related Subject Headings

  • Synaptic Transmission
  • Serotonin
  • Prospective Studies
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Pain, Postoperative
  • Middle Aged
  • Longitudinal Studies
  • Humans
  • Genotype