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Hereditary prostate cancer in African American families: linkage analysis using markers that map to five candidate susceptibility loci.

Publication ,  Journal Article
Brown, WM; Lange, EM; Chen, H; Zheng, SL; Chang, B; Wiley, KE; Isaacs, SD; Walsh, PC; Isaacs, WB; Xu, J; Cooney, KA
Published in: Br J Cancer
January 26, 2004

African American men have the highest incidence of prostate cancer in the world. Despite this statistic, linkage studies designed to localise prostate cancer susceptibility alleles have included primarily men of Caucasian descent. In this report, we performed a linkage analysis using 33 African American prostate cancer families from two independent research groups. In total, 126 individuals (including 89 men with prostate cancer) were genotyped using markers that map to five prostate cancer susceptibility loci, namely HPC1 at 1q24-25, PCAP at 1q42.2-43, CAPB at 1p36, HPC20 on chromosome 20, and HPCX at Xq27-28. Multipoint mode-of-inheritance-free linkage analyses were performed using the GENEHUNTER software. Some evidence of prostate cancer was detected to HPC1 using all families with a maximum NPL Z score of 1.12 near marker D1S413 (P=0.13). Increased evidence of linkage was observed in the 24 families with prostate cancer diagnosis prior to age 65 years and in the 20 families with male-to-male transmission. Some evidence of prostate cancer linkage was also detected at markers mapping to PCAP, HPC20, and HPCX. Continued collection and analysis of African American prostate cancer families will lead to an improved understanding of inherited susceptibility in this high-risk group.

Duke Scholars

Published In

Br J Cancer

DOI

ISSN

0007-0920

Publication Date

January 26, 2004

Volume

90

Issue

2

Start / End Page

510 / 514

Location

England

Related Subject Headings

  • Software
  • Prostatic Neoplasms
  • Polymerase Chain Reaction
  • Pedigree
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Brown, W. M., Lange, E. M., Chen, H., Zheng, S. L., Chang, B., Wiley, K. E., … Cooney, K. A. (2004). Hereditary prostate cancer in African American families: linkage analysis using markers that map to five candidate susceptibility loci. Br J Cancer, 90(2), 510–514. https://doi.org/10.1038/sj.bjc.6601417
Brown, W. M., E. M. Lange, H. Chen, S. L. Zheng, B. Chang, K. E. Wiley, S. D. Isaacs, et al. “Hereditary prostate cancer in African American families: linkage analysis using markers that map to five candidate susceptibility loci.Br J Cancer 90, no. 2 (January 26, 2004): 510–14. https://doi.org/10.1038/sj.bjc.6601417.
Brown WM, Lange EM, Chen H, Zheng SL, Chang B, Wiley KE, et al. Hereditary prostate cancer in African American families: linkage analysis using markers that map to five candidate susceptibility loci. Br J Cancer. 2004 Jan 26;90(2):510–4.
Brown, W. M., et al. “Hereditary prostate cancer in African American families: linkage analysis using markers that map to five candidate susceptibility loci.Br J Cancer, vol. 90, no. 2, Jan. 2004, pp. 510–14. Pubmed, doi:10.1038/sj.bjc.6601417.
Brown WM, Lange EM, Chen H, Zheng SL, Chang B, Wiley KE, Isaacs SD, Walsh PC, Isaacs WB, Xu J, Cooney KA. Hereditary prostate cancer in African American families: linkage analysis using markers that map to five candidate susceptibility loci. Br J Cancer. 2004 Jan 26;90(2):510–514.

Published In

Br J Cancer

DOI

ISSN

0007-0920

Publication Date

January 26, 2004

Volume

90

Issue

2

Start / End Page

510 / 514

Location

England

Related Subject Headings

  • Software
  • Prostatic Neoplasms
  • Polymerase Chain Reaction
  • Pedigree
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Genotype
  • Genetic Predisposition to Disease