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Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.

Publication ,  Journal Article
Eeles, RA; Kote-Jarai, Z; Al Olama, AA; Giles, GG; Guy, M; Severi, G; Muir, K; Hopper, JL; Henderson, BE; Haiman, CA; Schleutker, J; Hamdy, FC ...
Published in: Nat Genet
October 2009

Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 x 10(-8) to P = 2.7 x 10(-33)).

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Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

October 2009

Volume

41

Issue

10

Start / End Page

1116 / 1121

Location

United States

Related Subject Headings

  • Prostatic Neoplasms
  • Polymorphism, Single Nucleotide
  • Male
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Genome, Human
  • Disease Susceptibility
  • Developmental Biology
  • Chromosomes, Human
 

Citation

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Chicago
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Eeles, R. A., Kote-Jarai, Z., Al Olama, A. A., Giles, G. G., Guy, M., Severi, G., … Easton, D. F. (2009). Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nat Genet, 41(10), 1116–1121. https://doi.org/10.1038/ng.450
Eeles, Rosalind A., Zsofia Kote-Jarai, Ali Amin Al Olama, Graham G. Giles, Michelle Guy, Gianluca Severi, Kenneth Muir, et al. “Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.Nat Genet 41, no. 10 (October 2009): 1116–21. https://doi.org/10.1038/ng.450.
Eeles RA, Kote-Jarai Z, Al Olama AA, Giles GG, Guy M, Severi G, et al. Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nat Genet. 2009 Oct;41(10):1116–21.
Eeles, Rosalind A., et al. “Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.Nat Genet, vol. 41, no. 10, Oct. 2009, pp. 1116–21. Pubmed, doi:10.1038/ng.450.
Eeles RA, Kote-Jarai Z, Al Olama AA, Giles GG, Guy M, Severi G, Muir K, Hopper JL, Henderson BE, Haiman CA, Schleutker J, Hamdy FC, Neal DE, Donovan JL, Stanford JL, Ostrander EA, Ingles SA, John EM, Thibodeau SN, Schaid D, Park JY, Spurdle A, Clements J, Dickinson JL, Maier C, Vogel W, Dörk T, Rebbeck TR, Cooney KA, Cannon-Albright L, Chappuis PO, Hutter P, Zeegers M, Kaneva R, Zhang H-W, Lu Y-J, Foulkes WD, English DR, Leongamornlert DA, Tymrakiewicz M, Morrison J, Ardern-Jones AT, Hall AL, O’Brien LT, Wilkinson RA, Saunders EJ, Page EC, Sawyer EJ, Edwards SM, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As N, Woodhouse CJ, Thompson A, Christmas T, Ogden C, Cooper CS, Southey MC, Lophatananon A, Liu J-F, Kolonel LN, Le Marchand L, Wahlfors T, Tammela TL, Auvinen A, Lewis SJ, Cox A, FitzGerald LM, Koopmeiners JS, Karyadi DM, Kwon EM, Stern MC, Corral R, Joshi AD, Shahabi A, McDonnell SK, Sellers TA, Pow-Sang J, Chambers S, Aitken J, Gardiner RAF, Batra J, Kedda MA, Lose F, Polanowski A, Patterson B, Serth J, Meyer A, Luedeke M, Stefflova K, Ray AM, Lange EM, Farnham J, Khan H, Slavov C, Mitkova A, Cao G, UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons’ Section of Oncology, UK ProtecT Study Collaborators, PRACTICAL Consortium, Easton DF. Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nat Genet. 2009 Oct;41(10):1116–1121.

Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

October 2009

Volume

41

Issue

10

Start / End Page

1116 / 1121

Location

United States

Related Subject Headings

  • Prostatic Neoplasms
  • Polymorphism, Single Nucleotide
  • Male
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Genome, Human
  • Disease Susceptibility
  • Developmental Biology
  • Chromosomes, Human