Multiple regions within 8q24 independently affect risk for prostate cancer.
Publication
, Journal Article
Haiman, CA; Patterson, N; Freedman, ML; Myers, SR; Pike, MC; Waliszewska, A; Neubauer, J; Tandon, A; Schirmer, C; McDonald, GJ; Greenway, SC ...
Published in: Nat Genet
May 2007
After the recent discovery that common genetic variation in 8q24 influences inherited risk of prostate cancer, we genotyped 2,973 SNPs in up to 7,518 men with and without prostate cancer from five populations. We identified seven risk variants, five of them previously undescribed, spanning 430 kb and each independently predicting risk for prostate cancer (P = 7.9 x 10(-19) for the strongest association, and P < 1.5 x 10(-4) for five of the variants, after controlling for each of the others). The variants define common genotypes that span a more than fivefold range of susceptibility to cancer in some populations. None of the prostate cancer risk variants aligns to a known gene or alters the coding sequence of an encoded protein.
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Published In
Nat Genet
DOI
ISSN
1061-4036
Publication Date
May 2007
Volume
39
Issue
5
Start / End Page
638 / 644
Location
United States
Related Subject Headings
- White People
- United States
- Risk Factors
- Prostatic Neoplasms
- Polymorphism, Single Nucleotide
- Odds Ratio
- Male
- Humans
- Haplotypes
- Genotype
Citation
APA
Chicago
ICMJE
MLA
NLM
Haiman, C. A., Patterson, N., Freedman, M. L., Myers, S. R., Pike, M. C., Waliszewska, A., … Reich, D. (2007). Multiple regions within 8q24 independently affect risk for prostate cancer. Nat Genet, 39(5), 638–644. https://doi.org/10.1038/ng2015
Haiman, Christopher A., Nick Patterson, Matthew L. Freedman, Simon R. Myers, Malcolm C. Pike, Alicja Waliszewska, Julie Neubauer, et al. “Multiple regions within 8q24 independently affect risk for prostate cancer.” Nat Genet 39, no. 5 (May 2007): 638–44. https://doi.org/10.1038/ng2015.
Haiman CA, Patterson N, Freedman ML, Myers SR, Pike MC, Waliszewska A, et al. Multiple regions within 8q24 independently affect risk for prostate cancer. Nat Genet. 2007 May;39(5):638–44.
Haiman, Christopher A., et al. “Multiple regions within 8q24 independently affect risk for prostate cancer.” Nat Genet, vol. 39, no. 5, May 2007, pp. 638–44. Pubmed, doi:10.1038/ng2015.
Haiman CA, Patterson N, Freedman ML, Myers SR, Pike MC, Waliszewska A, Neubauer J, Tandon A, Schirmer C, McDonald GJ, Greenway SC, Stram DO, Le Marchand L, Kolonel LN, Frasco M, Wong D, Pooler LC, Ardlie K, Oakley-Girvan I, Whittemore AS, Cooney KA, John EM, Ingles SA, Altshuler D, Henderson BE, Reich D. Multiple regions within 8q24 independently affect risk for prostate cancer. Nat Genet. 2007 May;39(5):638–644.
Published In
Nat Genet
DOI
ISSN
1061-4036
Publication Date
May 2007
Volume
39
Issue
5
Start / End Page
638 / 644
Location
United States
Related Subject Headings
- White People
- United States
- Risk Factors
- Prostatic Neoplasms
- Polymorphism, Single Nucleotide
- Odds Ratio
- Male
- Humans
- Haplotypes
- Genotype