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Morphology in the Digital Age: Integrating High-Resolution Description of Structural Alterations With Phenotypes and Genotypes.

Publication ,  Journal Article
Nast, CC; Lemley, KV; Hodgin, JB; Bagnasco, S; Avila-Casado, C; Hewitt, SM; Barisoni, L
Published in: Semin Nephrol
May 2015

Conventional light microscopy has been used to characterize and classify renal diseases, evaluate histopathology in studies and trials, and educate renal pathologists and nephrologists. The advent of digital pathology, in which a glass slide can be scanned to create whole slide images (WSIs) for viewing and manipulating on a computer monitor, provides real and potential advantages compared with conventional light microscopy. Software tools such as annotation, morphometry, and image analysis can be applied to WSIs for studies or educational purposes, and the digital images are available globally to clinicians, pathologists, and investigators. New ways of assessing renal pathology with observational data collection may allow better morphologic correlations and integration with molecular and genetic signatures, refinements of classification schema, and understanding of disease pathogenesis. In multicenter studies, WSIs, which require additional quality assurance steps, provide efficiency by reducing slide shipping and consensus conference costs, and they allow slide viewing anytime and anywhere. Although validation studies for the routine diagnostic use of digital pathology still are needed, this is a powerful tool currently available for translational research, clinical trials, and education in renal pathology.

Duke Scholars

Published In

Semin Nephrol

DOI

EISSN

1558-4488

Publication Date

May 2015

Volume

35

Issue

3

Start / End Page

266 / 278

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Phenotype
  • Microscopy
  • Kidney Diseases
  • Kidney
  • Image Processing, Computer-Assisted
  • Humans
  • Genotype
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Nast, C. C., Lemley, K. V., Hodgin, J. B., Bagnasco, S., Avila-Casado, C., Hewitt, S. M., & Barisoni, L. (2015). Morphology in the Digital Age: Integrating High-Resolution Description of Structural Alterations With Phenotypes and Genotypes. Semin Nephrol, 35(3), 266–278. https://doi.org/10.1016/j.semnephrol.2015.04.006
Nast, Cynthia C., Kevin V. Lemley, Jeffrey B. Hodgin, Serena Bagnasco, Carmen Avila-Casado, Stephen M. Hewitt, and Laura Barisoni. “Morphology in the Digital Age: Integrating High-Resolution Description of Structural Alterations With Phenotypes and Genotypes.Semin Nephrol 35, no. 3 (May 2015): 266–78. https://doi.org/10.1016/j.semnephrol.2015.04.006.
Nast CC, Lemley KV, Hodgin JB, Bagnasco S, Avila-Casado C, Hewitt SM, et al. Morphology in the Digital Age: Integrating High-Resolution Description of Structural Alterations With Phenotypes and Genotypes. Semin Nephrol. 2015 May;35(3):266–78.
Nast, Cynthia C., et al. “Morphology in the Digital Age: Integrating High-Resolution Description of Structural Alterations With Phenotypes and Genotypes.Semin Nephrol, vol. 35, no. 3, May 2015, pp. 266–78. Pubmed, doi:10.1016/j.semnephrol.2015.04.006.
Nast CC, Lemley KV, Hodgin JB, Bagnasco S, Avila-Casado C, Hewitt SM, Barisoni L. Morphology in the Digital Age: Integrating High-Resolution Description of Structural Alterations With Phenotypes and Genotypes. Semin Nephrol. 2015 May;35(3):266–278.
Journal cover image

Published In

Semin Nephrol

DOI

EISSN

1558-4488

Publication Date

May 2015

Volume

35

Issue

3

Start / End Page

266 / 278

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Phenotype
  • Microscopy
  • Kidney Diseases
  • Kidney
  • Image Processing, Computer-Assisted
  • Humans
  • Genotype
  • 3202 Clinical sciences
  • 1103 Clinical Sciences