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Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach.

Publication ,  Journal Article
Gadegbeku, CA; Gipson, DS; Holzman, LB; Ojo, AO; Song, PXK; Barisoni, L; Sampson, MG; Kopp, JB; Lemley, KV; Nelson, PJ; Lienczewski, CC ...
Published in: Kidney Int
April 2013

The Nephrotic Syndrome Study Network (NEPTUNE) is a North American multicenter collaborative consortium established to develop a translational research infrastructure for nephrotic syndrome. This includes a longitudinal observational cohort study, a pilot and ancillary study program, a training program, and a patient contact registry. NEPTUNE will enroll 450 adults and children with minimal change disease, focal segmental glomerulosclerosis, and membranous nephropathy for detailed clinical, histopathological, and molecular phenotyping at the time of clinically indicated renal biopsy. Initial visits will include an extensive clinical history, physical examination, collection of urine, blood and renal tissue samples, and assessments of quality of life and patient-reported outcomes. Follow-up history, physical measures, urine and blood samples, and questionnaires will be obtained every 4 months in the first year and biannually, thereafter. Molecular profiles and gene expression data will be linked to phenotypic, genetic, and digitalized histological data for comprehensive analyses using systems biology approaches. Analytical strategies were designed to transform descriptive information to mechanistic disease classification for nephrotic syndrome and to identify clinical, histological, and genomic disease predictors. Thus, understanding the complexity of the disease pathogenesis will guide further investigation for targeted therapeutic strategies.

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Published In

Kidney Int

DOI

EISSN

1523-1755

Publication Date

April 2013

Volume

83

Issue

4

Start / End Page

749 / 756

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Translational Research, Biomedical
  • Time Factors
  • Systems Biology
  • Surveys and Questionnaires
  • Risk Factors
  • Research Design
  • Registries
  • Prospective Studies
  • Prognosis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gadegbeku, C. A., Gipson, D. S., Holzman, L. B., Ojo, A. O., Song, P. X. K., Barisoni, L., … Kretzler, M. (2013). Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach. Kidney Int, 83(4), 749–756. https://doi.org/10.1038/ki.2012.428
Gadegbeku, Crystal A., Debbie S. Gipson, Lawrence B. Holzman, Akinlolu O. Ojo, Peter X. K. Song, Laura Barisoni, Matthew G. Sampson, et al. “Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach.Kidney Int 83, no. 4 (April 2013): 749–56. https://doi.org/10.1038/ki.2012.428.
Gadegbeku CA, Gipson DS, Holzman LB, Ojo AO, Song PXK, Barisoni L, et al. Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach. Kidney Int. 2013 Apr;83(4):749–56.
Gadegbeku, Crystal A., et al. “Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach.Kidney Int, vol. 83, no. 4, Apr. 2013, pp. 749–56. Pubmed, doi:10.1038/ki.2012.428.
Gadegbeku CA, Gipson DS, Holzman LB, Ojo AO, Song PXK, Barisoni L, Sampson MG, Kopp JB, Lemley KV, Nelson PJ, Lienczewski CC, Adler SG, Appel GB, Cattran DC, Choi MJ, Contreras G, Dell KM, Fervenza FC, Gibson KL, Greenbaum LA, Hernandez JD, Hewitt SM, Hingorani SR, Hladunewich M, Hogan MC, Hogan SL, Kaskel FJ, Lieske JC, Meyers KEC, Nachman PH, Nast CC, Neu AM, Reich HN, Sedor JR, Sethna CB, Trachtman H, Tuttle KR, Zhdanova O, Zilleruelo GE, Kretzler M. Design of the Nephrotic Syndrome Study Network (NEPTUNE) to evaluate primary glomerular nephropathy by a multidisciplinary approach. Kidney Int. 2013 Apr;83(4):749–756.
Journal cover image

Published In

Kidney Int

DOI

EISSN

1523-1755

Publication Date

April 2013

Volume

83

Issue

4

Start / End Page

749 / 756

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Translational Research, Biomedical
  • Time Factors
  • Systems Biology
  • Surveys and Questionnaires
  • Risk Factors
  • Research Design
  • Registries
  • Prospective Studies
  • Prognosis