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Update in podocyte biology: putting one's best foot forward.

Publication ,  Journal Article
Barisoni, L; Kopp, JB
Published in: Current opinion in nephrology and hypertension
May 2003

The rapidly developing field of podocyte cell biology is reviewed, focusing on papers published in the last 12 months.Four areas of particular progress can be discerned. First, podocytes proliferate during early metanephric development, are quiescent after the capillary loop stage, and re-enter the cell cycle only in the disease group termed collapsing glomerulopathy. We have learned that control of the podocyte cell cycle involves both expression of cell-cycle regulating proteins and the process of cytokinesis. Second, the podocyte slit diaphragm is the final component of the filtration barrier. The structure and maintenance of the slit diaphragm has been a major focus of research activity, and a multiplicity of relevant molecular interactions have been defined. Significant advances have been made in understanding the complex and interacting role of nephrin and podocin mutations in the genesis of clinical glomerular disease. Third, several proteins essential to controlling discrete podocyte transcriptional programs have been defined. Finally, conditionally-immortalized podocyte cell lines, derived from mouse and human tissue, have proven their worth as models to advance investigations of podocyte biology.Podocyte injury occurs as a consequence of genetic mutation, immunological injury, viral infection, or abnormal hemodynamic forces within the glomerulus. As we understand more about the podocyte proteome and cell biology, we gain an increasingly detailed molecular understanding of podocyte structure and function. In this drama we have many molecular players and increasing stretches of molecular dialogue, but the script remains largely to be deciphered. Nevertheless, we do understand the consequences that arise when the podocyte cannot put its best foot (processes) forward.

Duke Scholars

Published In

Current opinion in nephrology and hypertension

DOI

EISSN

1473-6543

ISSN

1062-4821

Publication Date

May 2003

Volume

12

Issue

3

Start / End Page

251 / 258

Related Subject Headings

  • Urology & Nephrology
  • Transcription, Genetic
  • Proteins
  • Mutation
  • Membrane Proteins
  • Kidney Glomerulus
  • Kidney Diseases
  • Intracellular Signaling Peptides and Proteins
  • Humans
  • Cells, Cultured
 

Citation

APA
Chicago
ICMJE
MLA
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Barisoni, L., & Kopp, J. B. (2003). Update in podocyte biology: putting one's best foot forward. Current Opinion in Nephrology and Hypertension, 12(3), 251–258. https://doi.org/10.1097/00041552-200305000-00005
Barisoni, Laura, and Jeffrey B. Kopp. “Update in podocyte biology: putting one's best foot forward.Current Opinion in Nephrology and Hypertension 12, no. 3 (May 2003): 251–58. https://doi.org/10.1097/00041552-200305000-00005.
Barisoni L, Kopp JB. Update in podocyte biology: putting one's best foot forward. Current opinion in nephrology and hypertension. 2003 May;12(3):251–8.
Barisoni, Laura, and Jeffrey B. Kopp. “Update in podocyte biology: putting one's best foot forward.Current Opinion in Nephrology and Hypertension, vol. 12, no. 3, May 2003, pp. 251–58. Epmc, doi:10.1097/00041552-200305000-00005.
Barisoni L, Kopp JB. Update in podocyte biology: putting one's best foot forward. Current opinion in nephrology and hypertension. 2003 May;12(3):251–258.

Published In

Current opinion in nephrology and hypertension

DOI

EISSN

1473-6543

ISSN

1062-4821

Publication Date

May 2003

Volume

12

Issue

3

Start / End Page

251 / 258

Related Subject Headings

  • Urology & Nephrology
  • Transcription, Genetic
  • Proteins
  • Mutation
  • Membrane Proteins
  • Kidney Glomerulus
  • Kidney Diseases
  • Intracellular Signaling Peptides and Proteins
  • Humans
  • Cells, Cultured