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A proposed taxonomy for the podocytopathies: a reassessment of the primary nephrotic diseases.

Publication ,  Journal Article
Barisoni, L; Schnaper, HW; Kopp, JB
Published in: Clin J Am Soc Nephrol
May 2007

A spectrum of proteinuric glomerular diseases results from podocyte abnormalities. The understanding of these podocytopathies has greatly expanded in recent years, particularly with the discovery of more than a dozen genetic mutations that are associated with loss of podocyte functional integrity. It is apparent that classification of the podocytopathies on the basis of morphology alone is inadequate to capture fully the complexity of these disorders. Herein is proposed a taxonomy for the podocytopathies that classifies along two dimensions: Histopathology, including podocyte phenotype and glomerular morphology (minimal-change nephropathy, focal segmental glomerulosclerosis, diffuse mesangial sclerosis, and collapsing glomerulopathy), and etiology (idiopathic, genetic, and reactive forms). A more complete understanding of the similarities and differences among podocyte diseases will help the renal pathologist and the nephrologist communicate more effectively about the diagnosis; this in turn will help the nephrologist provide more accurate prognostic information and select the optimal therapy for these often problematic diseases. It is proposed that final diagnosis of the podocytopathies should result from close collaboration between renal pathologists and nephrologists and should whenever possible include three elements: Morphologic entity, etiologic form, and specific pathogenic mechanism or association.

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Published In

Clin J Am Soc Nephrol

DOI

EISSN

1555-905X

Publication Date

May 2007

Volume

2

Issue

3

Start / End Page

529 / 542

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Proteinuria
  • Podocytes
  • Kidney Glomerulus
  • Kidney Diseases
  • Humans
  • 4202 Epidemiology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Barisoni, L., Schnaper, H. W., & Kopp, J. B. (2007). A proposed taxonomy for the podocytopathies: a reassessment of the primary nephrotic diseases. Clin J Am Soc Nephrol, 2(3), 529–542. https://doi.org/10.2215/CJN.04121206
Barisoni, Laura, H William Schnaper, and Jeffrey B. Kopp. “A proposed taxonomy for the podocytopathies: a reassessment of the primary nephrotic diseases.Clin J Am Soc Nephrol 2, no. 3 (May 2007): 529–42. https://doi.org/10.2215/CJN.04121206.
Barisoni L, Schnaper HW, Kopp JB. A proposed taxonomy for the podocytopathies: a reassessment of the primary nephrotic diseases. Clin J Am Soc Nephrol. 2007 May;2(3):529–42.
Barisoni, Laura, et al. “A proposed taxonomy for the podocytopathies: a reassessment of the primary nephrotic diseases.Clin J Am Soc Nephrol, vol. 2, no. 3, May 2007, pp. 529–42. Pubmed, doi:10.2215/CJN.04121206.
Barisoni L, Schnaper HW, Kopp JB. A proposed taxonomy for the podocytopathies: a reassessment of the primary nephrotic diseases. Clin J Am Soc Nephrol. 2007 May;2(3):529–542.

Published In

Clin J Am Soc Nephrol

DOI

EISSN

1555-905X

Publication Date

May 2007

Volume

2

Issue

3

Start / End Page

529 / 542

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Proteinuria
  • Podocytes
  • Kidney Glomerulus
  • Kidney Diseases
  • Humans
  • 4202 Epidemiology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences