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CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney.

Publication ,  Journal Article
Soos, TJ; Sims, TN; Barisoni, L; Lin, K; Littman, DR; Dustin, ML; Nelson, PJ
Published in: Kidney Int
August 2006

Dendritic cells (DCs) interface innate and adaptive immunity in nonlymphoid organs; however, the exact distribution and types of DC within the kidney are not known. We utilized CX3CR1GFP/+ mice to characterize the anatomy and phenotype of tissue-resident CX3CR1+ DCs within normal kidney. Laser-scanning confocal microscopy revealed an extensive, contiguous network of stellate-shaped CX3CR1+ DCs throughout the interstitial and mesangial spaces of the entire kidney. Intravital microscopy of the superficial cortex showed stationary interstitial CX3CR1+ DCs that continually probe the surrounding tissue environment through dendrite extensions. Flow cytometry of renal CX3CR1+ DCs showed significant coexpression of CD11c and F4/80, high major histocompatibility complex class II and FcR expression, and immature costimulatory but competent phagocytic ability indicative of tissue-resident, immature DCs ready to respond to environment cues. Thus, within the renal parenchyma, there exists little immunological privilege from the surveillance provided by renal CX3CR1+ DCs, a major constituent of the heterogeneous mononuclear phagocyte system populating normal kidney.

Duke Scholars

Published In

Kidney Int

DOI

ISSN

0085-2538

Publication Date

August 2006

Volume

70

Issue

3

Start / End Page

591 / 596

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Receptors, Chemokine
  • Phagocytes
  • Mice, Transgenic
  • Mice
  • Kidney
  • Immune System
  • Green Fluorescent Proteins
  • Flow Cytometry
  • Dendritic Cells
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Soos, T. J., Sims, T. N., Barisoni, L., Lin, K., Littman, D. R., Dustin, M. L., & Nelson, P. J. (2006). CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney. Kidney Int, 70(3), 591–596. https://doi.org/10.1038/sj.ki.5001567
Soos, T. J., T. N. Sims, L. Barisoni, K. Lin, D. R. Littman, M. L. Dustin, and P. J. Nelson. “CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney.Kidney Int 70, no. 3 (August 2006): 591–96. https://doi.org/10.1038/sj.ki.5001567.
Soos TJ, Sims TN, Barisoni L, Lin K, Littman DR, Dustin ML, et al. CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney. Kidney Int. 2006 Aug;70(3):591–6.
Soos, T. J., et al. “CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney.Kidney Int, vol. 70, no. 3, Aug. 2006, pp. 591–96. Pubmed, doi:10.1038/sj.ki.5001567.
Soos TJ, Sims TN, Barisoni L, Lin K, Littman DR, Dustin ML, Nelson PJ. CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney. Kidney Int. 2006 Aug;70(3):591–596.
Journal cover image

Published In

Kidney Int

DOI

ISSN

0085-2538

Publication Date

August 2006

Volume

70

Issue

3

Start / End Page

591 / 596

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Receptors, Chemokine
  • Phagocytes
  • Mice, Transgenic
  • Mice
  • Kidney
  • Immune System
  • Green Fluorescent Proteins
  • Flow Cytometry
  • Dendritic Cells