Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

CD20-positive infiltrates in renal allograft biopsies with acute cellular rejection are not associated with worse graft survival.

Publication ,  Journal Article
Bagnasco, SM; Tsai, W; Rahman, MH; Kraus, ES; Barisoni, L; Vega, R; Racusen, LC; Haas, M; Mohammed, BS; Zachary, AA; Montgomery, RA
Published in: Am J Transplant
August 2007

We examined rejection outcome and graft survival in 58 adult patients with acute cellular rejection Banff type I (ARI) or II (ARII), within 1 year after transplantation, with or without CD20-positive infiltrates. Antibody-mediated rejection was not examined. Of the 74 allograft biopsies, performed from 1999 to 2001, 40 biopsies showed ARI and 34 biopsies showed ARII; 30% of all the biopsies showed CD20-positive clusters with more than 100 cells, 9% with more than 200 cells and 5% with more than 275 cells. Patients with B cell-rich (>100 or >200/HPF CD20-positive cells) and B cell-poor biopsies (<50 CD20-positive cells/HPF) were compared. Serum creatinine and eGFR of B cell-rich (CD20 > 100/HPF) and B cell-poor were not significantly different at rejection, or at 1, 3, 6 and 12 months, and during additional 3 years follow-up after rejection, although higher creatinine at 1 year was noted in the >200/HPF group. Graft survival was also not different between B cell-rich and B cell-poor groups (p = 0.8 for >100/HPF, p = 0.9 for >200/HPF CD20-positive cells). Our data do not support association of B cell-rich infiltrates in allograft biopsies and worse outcome in acute rejection type I or II, but do not exclude the possible contribution of B cells to allograft rejection.

Duke Scholars

Published In

Am J Transplant

DOI

ISSN

1600-6135

Publication Date

August 2007

Volume

7

Issue

8

Start / End Page

1968 / 1973

Location

United States

Related Subject Headings

  • Time Factors
  • Surgery
  • Severity of Illness Index
  • Retrospective Studies
  • Prognosis
  • Middle Aged
  • Male
  • Kidney Transplantation
  • Humans
  • Graft Survival
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bagnasco, S. M., Tsai, W., Rahman, M. H., Kraus, E. S., Barisoni, L., Vega, R., … Montgomery, R. A. (2007). CD20-positive infiltrates in renal allograft biopsies with acute cellular rejection are not associated with worse graft survival. Am J Transplant, 7(8), 1968–1973. https://doi.org/10.1111/j.1600-6143.2007.01885.x
Bagnasco, S. M., W. Tsai, M. H. Rahman, E. S. Kraus, L. Barisoni, R. Vega, L. C. Racusen, et al. “CD20-positive infiltrates in renal allograft biopsies with acute cellular rejection are not associated with worse graft survival.Am J Transplant 7, no. 8 (August 2007): 1968–73. https://doi.org/10.1111/j.1600-6143.2007.01885.x.
Bagnasco SM, Tsai W, Rahman MH, Kraus ES, Barisoni L, Vega R, et al. CD20-positive infiltrates in renal allograft biopsies with acute cellular rejection are not associated with worse graft survival. Am J Transplant. 2007 Aug;7(8):1968–73.
Bagnasco, S. M., et al. “CD20-positive infiltrates in renal allograft biopsies with acute cellular rejection are not associated with worse graft survival.Am J Transplant, vol. 7, no. 8, Aug. 2007, pp. 1968–73. Pubmed, doi:10.1111/j.1600-6143.2007.01885.x.
Bagnasco SM, Tsai W, Rahman MH, Kraus ES, Barisoni L, Vega R, Racusen LC, Haas M, Mohammed BS, Zachary AA, Montgomery RA. CD20-positive infiltrates in renal allograft biopsies with acute cellular rejection are not associated with worse graft survival. Am J Transplant. 2007 Aug;7(8):1968–1973.
Journal cover image

Published In

Am J Transplant

DOI

ISSN

1600-6135

Publication Date

August 2007

Volume

7

Issue

8

Start / End Page

1968 / 1973

Location

United States

Related Subject Headings

  • Time Factors
  • Surgery
  • Severity of Illness Index
  • Retrospective Studies
  • Prognosis
  • Middle Aged
  • Male
  • Kidney Transplantation
  • Humans
  • Graft Survival