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The kd/kd mouse is a model of collapsing glomerulopathy.

Publication ,  Journal Article
Barisoni, L; Madaio, MP; Eraso, M; Gasser, DL; Nelson, PJ
Published in: J Am Soc Nephrol
October 2005

Collapsing glomerulopathy (CG) is associated with disorders that markedly perturb the phenotype of podocytes. The kd/kd mouse has been studied for immune and genetic causes of microcystic tubulointerstitial nephritis with little attention to its glomerular lesion. Because histologic examination revealed classic morphologic features of CG, the question arises whether podocytes in kd/kd mice exhibit additional phenotypic criteria for CG. Utilizing Tg26 mice as a positive control, immunohistochemical profiling of the podocyte phenotype was conducted simultaneously on both models. Similar to Tg26 kidneys, podocytes in kd/kd kidneys showed de novo cyclin D1, Ki-67, and desmin expression with loss of synaptopodin and WT-1 expression. Electron micrographs showed collapsed capillaries, extensive foot process effacement, and dysmorphic mitochondria in podocytes. These results indicate that the kd/kd mouse is a model of CG and raise the possibility that human equivalents of the kd susceptibility gene may exist in patients with CG.

Duke Scholars

Published In

J Am Soc Nephrol

DOI

ISSN

1046-6673

Publication Date

October 2005

Volume

16

Issue

10

Start / End Page

2847 / 2851

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Podocytes
  • Mice
  • Kidney Diseases
  • Disease Models, Animal
  • Animals
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Barisoni, L., Madaio, M. P., Eraso, M., Gasser, D. L., & Nelson, P. J. (2005). The kd/kd mouse is a model of collapsing glomerulopathy. J Am Soc Nephrol, 16(10), 2847–2851. https://doi.org/10.1681/ASN.2005050494
Barisoni, Laura, Michael P. Madaio, Maria Eraso, David L. Gasser, and Peter J. Nelson. “The kd/kd mouse is a model of collapsing glomerulopathy.J Am Soc Nephrol 16, no. 10 (October 2005): 2847–51. https://doi.org/10.1681/ASN.2005050494.
Barisoni L, Madaio MP, Eraso M, Gasser DL, Nelson PJ. The kd/kd mouse is a model of collapsing glomerulopathy. J Am Soc Nephrol. 2005 Oct;16(10):2847–51.
Barisoni, Laura, et al. “The kd/kd mouse is a model of collapsing glomerulopathy.J Am Soc Nephrol, vol. 16, no. 10, Oct. 2005, pp. 2847–51. Pubmed, doi:10.1681/ASN.2005050494.
Barisoni L, Madaio MP, Eraso M, Gasser DL, Nelson PJ. The kd/kd mouse is a model of collapsing glomerulopathy. J Am Soc Nephrol. 2005 Oct;16(10):2847–2851.

Published In

J Am Soc Nephrol

DOI

ISSN

1046-6673

Publication Date

October 2005

Volume

16

Issue

10

Start / End Page

2847 / 2851

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Podocytes
  • Mice
  • Kidney Diseases
  • Disease Models, Animal
  • Animals
  • 3202 Clinical sciences
  • 1103 Clinical Sciences