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Cytokines as biomarkers of inflammatory response after open versus endovascular repair of abdominal aortic aneurysms: a systematic review.

Publication ,  Journal Article
Tsilimigras, DI; Sigala, F; Karaolanis, G; Ntanasis-Stathopoulos, I; Spartalis, E; Spartalis, M; Patelis, N; Papalampros, A; Long, C; Moris, D
Published in: Acta Pharmacol Sin
July 2018

The repair of an abdominal aortic aneurysm (AAA) is a high-risk surgical procedure related to hormonal and metabolic stress-related response with an ensuing activation of the inflammatory cascade. In contrast to open repair (OR), endovascular aortic aneurysm repair (EVAR) seems to decrease the postoperative stress by offering less extensive incisions, dissection, and tissue manipulation. However, these beneficial effects may be offset by the release of cytokines and arachidonic acid metabolites during intra-luminal manipulation of the thrombus using catheters in endovascular repair, resulting in systemic inflammatory response (SIR), which is clinically called post-implantation syndrome. In this systematic review we compared OR with EVAR in terms of the post-interventional inflammatory response resulting from alterations in the circulating cytokine levels. We sought to summarize all the latest evidence regarding post-implantation syndrome after EVAR. We searched Medline (PubMed), ClinicalTrials.gov and the Cochrane library for clinical studies reporting on the release of cytokines as part of the inflammatory response after both open/conventional and endovascular repair of the AAA. We identified 17 studies examining the cytokine levels after OR versus EVAR. OR seemed to be associated with a greater SIR than EVAR, as evidenced by the increased cytokine levels, particularly IL-6 and IL-8, whereas IL-1β, IL-10 and TNF-α showed conflicting results or no difference between the two groups. Polyester endografts appear to be positively correlated with the incidence of post-implantation syndrome after EVAR. Future large prospective studies are warranted to delineate the underlying mechanisms of the cytokine interaction in the post-surgical inflammatory response setting.

Duke Scholars

Published In

Acta Pharmacol Sin

DOI

EISSN

1745-7254

Publication Date

July 2018

Volume

39

Issue

7

Start / End Page

1164 / 1175

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Pharmacology & Pharmacy
  • Inflammation
  • Humans
  • Endovascular Procedures
  • Cytokines
  • Biomarkers
  • Aortic Aneurysm, Abdominal
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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Tsilimigras, D. I., Sigala, F., Karaolanis, G., Ntanasis-Stathopoulos, I., Spartalis, E., Spartalis, M., … Moris, D. (2018). Cytokines as biomarkers of inflammatory response after open versus endovascular repair of abdominal aortic aneurysms: a systematic review. Acta Pharmacol Sin, 39(7), 1164–1175. https://doi.org/10.1038/aps.2017.212
Tsilimigras, Diamantis I., Fragiska Sigala, Georgios Karaolanis, Ioannis Ntanasis-Stathopoulos, Eleftherios Spartalis, Michael Spartalis, Nikolaos Patelis, Alexandros Papalampros, Chandler Long, and Demetrios Moris. “Cytokines as biomarkers of inflammatory response after open versus endovascular repair of abdominal aortic aneurysms: a systematic review.Acta Pharmacol Sin 39, no. 7 (July 2018): 1164–75. https://doi.org/10.1038/aps.2017.212.
Tsilimigras DI, Sigala F, Karaolanis G, Ntanasis-Stathopoulos I, Spartalis E, Spartalis M, et al. Cytokines as biomarkers of inflammatory response after open versus endovascular repair of abdominal aortic aneurysms: a systematic review. Acta Pharmacol Sin. 2018 Jul;39(7):1164–75.
Tsilimigras, Diamantis I., et al. “Cytokines as biomarkers of inflammatory response after open versus endovascular repair of abdominal aortic aneurysms: a systematic review.Acta Pharmacol Sin, vol. 39, no. 7, July 2018, pp. 1164–75. Pubmed, doi:10.1038/aps.2017.212.
Tsilimigras DI, Sigala F, Karaolanis G, Ntanasis-Stathopoulos I, Spartalis E, Spartalis M, Patelis N, Papalampros A, Long C, Moris D. Cytokines as biomarkers of inflammatory response after open versus endovascular repair of abdominal aortic aneurysms: a systematic review. Acta Pharmacol Sin. 2018 Jul;39(7):1164–1175.
Journal cover image

Published In

Acta Pharmacol Sin

DOI

EISSN

1745-7254

Publication Date

July 2018

Volume

39

Issue

7

Start / End Page

1164 / 1175

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Pharmacology & Pharmacy
  • Inflammation
  • Humans
  • Endovascular Procedures
  • Cytokines
  • Biomarkers
  • Aortic Aneurysm, Abdominal
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences