Skip to main content

GSK2193874 treatment at heatstroke onset reduced cell apoptosis in heatstroke mice.

Publication ,  Journal Article
Zhu, Y-H; Pei, Z-M
Published in: Cellular and molecular biology (Noisy-le-Grand, France)
May 2018

Heatstroke is still a potentially fatal threat during summer heat waves, despite improved prevention and treatment. It is reported that the transient receptor potential vanilloid 4 (TRPV4) inhibitor may protect septicemia mice. Many aspects of heatstroke have been defined, from the sepsis-mimic inflammatory response to hyperthermia. Hence, TRPV4 may be a therapeutic target for heatstroke. The results in murine models of heatstroke verified that GSK2193874, as a selected TRPV4 inhibitor, was injected at heatstroke onset, and then reduced the reduction of core temperature, the death rate, wet/dry ratio of the lung, levels of tumor necrosis factor-α (TNF-α) and interleukin (IL)-6, coagulation indicators, the degree of organ injury, and caspase-3/7 activity (P<0.05). But GSK2193874 treatment before heat stress did not improve the symptoms of heatstroke mice. Therefore, TRPV4 should be involved in heatstroke-induced injury. Timely GSK2193874 administration may be useful to reduce heatstroke-induced injury. TRPV4 may be a potential new therapeutic target in fatal heatstroke.

Duke Scholars

Published In

Cellular and molecular biology (Noisy-le-Grand, France)

EISSN

1165-158X

ISSN

0145-5680

Publication Date

May 2018

Volume

64

Issue

7

Start / End Page

36 / 42

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • TRPV Cation Channels
  • Quinolines
  • Pulmonary Edema
  • Piperidines
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Interleukin-6
  • Hot Temperature
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhu, Y.-H., & Pei, Z.-M. (2018). GSK2193874 treatment at heatstroke onset reduced cell apoptosis in heatstroke mice. Cellular and Molecular Biology (Noisy-Le-Grand, France), 64(7), 36–42.
Zhu, Yi-Hua, and Zhen-Ming Pei. “GSK2193874 treatment at heatstroke onset reduced cell apoptosis in heatstroke mice.Cellular and Molecular Biology (Noisy-Le-Grand, France) 64, no. 7 (May 2018): 36–42.
Zhu Y-H, Pei Z-M. GSK2193874 treatment at heatstroke onset reduced cell apoptosis in heatstroke mice. Cellular and molecular biology (Noisy-le-Grand, France). 2018 May;64(7):36–42.
Zhu, Yi-Hua, and Zhen-Ming Pei. “GSK2193874 treatment at heatstroke onset reduced cell apoptosis in heatstroke mice.Cellular and Molecular Biology (Noisy-Le-Grand, France), vol. 64, no. 7, May 2018, pp. 36–42.
Zhu Y-H, Pei Z-M. GSK2193874 treatment at heatstroke onset reduced cell apoptosis in heatstroke mice. Cellular and molecular biology (Noisy-le-Grand, France). 2018 May;64(7):36–42.

Published In

Cellular and molecular biology (Noisy-le-Grand, France)

EISSN

1165-158X

ISSN

0145-5680

Publication Date

May 2018

Volume

64

Issue

7

Start / End Page

36 / 42

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • TRPV Cation Channels
  • Quinolines
  • Pulmonary Edema
  • Piperidines
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Interleukin-6
  • Hot Temperature