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Interaction of oxytocin level and past depression may predict postpartum depressive symptom severity.

Publication ,  Journal Article
Massey, SH; Schuette, SA; Pournajafi-Nazarloo, H; Wisner, KL; Carter, CS
Published in: Arch Womens Ment Health
October 2016

We examined plasma oxytocin concentration and postpartum depression (PPD) symptom severity in women who were not depressed during pregnancy and whether this differed by major depressive disorder (MDD) history. We assessed psychiatric history and plasma oxytocin in 66 healthy pregnant women in the third trimester (M = 35 ± 3 weeks) and depressive symptoms at 6 weeks postpartum (M = 5.9 ± 0.8 weeks). Linear regression analysis was used to examine oxytocin and PPD symptom severity and moderation of oxytocin and PPD by past MDD. Women with (n = 13) and without (n = 53) past MDD differed in third trimester depressive symptom severity, but not oxytocin level, demographic factors, or birth outcomes. Controlling for third trimester depressive symptoms, oxytocin level was unrelated to PPD symptom severity [B(SE) = -.019 (.084); β = -.025; t = -.227; p = .821]. However, oxytocin level interacted with past MDD to predict PPD symptom severity [B(SE) = 7.489 (2.429); β = .328; t = 3.084; p = .003]. Higher oxytocin predicted greater PPD symptom severity in women with past MDD (p = .019), but not in women without (p = .216). Replication in a larger sample and methodologic challenges are discussed.

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Published In

Arch Womens Ment Health

DOI

EISSN

1435-1102

Publication Date

October 2016

Volume

19

Issue

5

Start / End Page

799 / 808

Location

Austria

Related Subject Headings

  • Severity of Illness Index
  • Risk Factors
  • Psychiatry
  • Pregnancy Trimester, Third
  • Pregnancy
  • Predictive Value of Tests
  • Oxytocin
  • Humans
  • Female
  • Depressive Disorder, Major
 

Citation

APA
Chicago
ICMJE
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Massey, S. H., Schuette, S. A., Pournajafi-Nazarloo, H., Wisner, K. L., & Carter, C. S. (2016). Interaction of oxytocin level and past depression may predict postpartum depressive symptom severity. Arch Womens Ment Health, 19(5), 799–808. https://doi.org/10.1007/s00737-016-0616-6
Massey, Suena H., Stephanie A. Schuette, Hossein Pournajafi-Nazarloo, Katherine L. Wisner, and C Sue Carter. “Interaction of oxytocin level and past depression may predict postpartum depressive symptom severity.Arch Womens Ment Health 19, no. 5 (October 2016): 799–808. https://doi.org/10.1007/s00737-016-0616-6.
Massey SH, Schuette SA, Pournajafi-Nazarloo H, Wisner KL, Carter CS. Interaction of oxytocin level and past depression may predict postpartum depressive symptom severity. Arch Womens Ment Health. 2016 Oct;19(5):799–808.
Massey, Suena H., et al. “Interaction of oxytocin level and past depression may predict postpartum depressive symptom severity.Arch Womens Ment Health, vol. 19, no. 5, Oct. 2016, pp. 799–808. Pubmed, doi:10.1007/s00737-016-0616-6.
Massey SH, Schuette SA, Pournajafi-Nazarloo H, Wisner KL, Carter CS. Interaction of oxytocin level and past depression may predict postpartum depressive symptom severity. Arch Womens Ment Health. 2016 Oct;19(5):799–808.
Journal cover image

Published In

Arch Womens Ment Health

DOI

EISSN

1435-1102

Publication Date

October 2016

Volume

19

Issue

5

Start / End Page

799 / 808

Location

Austria

Related Subject Headings

  • Severity of Illness Index
  • Risk Factors
  • Psychiatry
  • Pregnancy Trimester, Third
  • Pregnancy
  • Predictive Value of Tests
  • Oxytocin
  • Humans
  • Female
  • Depressive Disorder, Major