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Impact of hypertension on retinal capillary microvasculature using optical coherence tomographic angiography.

Publication ,  Journal Article
Chua, J; Chin, CWL; Hong, J; Chee, ML; Le, T-T; Ting, DSW; Wong, TY; Schmetterer, L
Published in: J Hypertens
March 2019

OBJECTIVE: Reduction in capillary density or rarefaction is a hallmark of essential hypertension. We measured the retinal capillary density using noninvasive optical coherence tomographic angiography (OCT-A) in adults with treated systemic hypertension and determined possible correlations with ambulatory blood pressure (BP) and renal parameters. METHODS: This observational cross-sectional study consisted of 153 normal eyes from 77 nondiabetic hypertensive adults [mean (SD) age, 58 (9) years; 49% women; 23% poorly controlled BP]. Data on 24-h ambulatory BP monitoring, serum creatinine, and urine microalbumin/creatinine ratio (MCR) were collected. Estimated glomerular filtration rate (eGFR) was calculated based on CKD-EPI Creatinine Equation. Retinal capillary density measured with the OCT-A (AngioVue) at superficial (SVP) and deep vascular plexuses (DVP). Linear regression was used to investigate the association of risk factors with capillary density. RESULTS: Retinal capillary density (percentage) at DVP was reduced in patients with poorly controlled BP (SBP = 148 ± 8 mmHg; 27.2 ± 13.0) compared with those with well controlled BP (SBP = 125 ± 9 mmHg; 34.7 ± 11.3). In the multivariable analysis, poorly controlled BP [β = -6.49, 95% confidence interval (CI), -12.39 to -0.59], higher SBP (β = -0.23, 95% CI -0.44 to -0.02) and lower eGFR (β = 6.42, 95% CI 1.25-11.60) were associated with sparser retinal capillary density. Systemic factors were not associated with capillary density at SVP (all P > 0.05). CONCLUSION: In adults with treated systemic hypertension, retinal capillary density reduced with higher BP and poorer eGFR. These findings highlight the potential role of OCT-A to study early microvascular changes because of systemic hypertension.

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Published In

J Hypertens

DOI

EISSN

1473-5598

Publication Date

March 2019

Volume

37

Issue

3

Start / End Page

572 / 580

Location

Netherlands

Related Subject Headings

  • Tomography, Optical Coherence
  • Retinal Vessels
  • Middle Aged
  • Microvessels
  • Male
  • Hypertension
  • Humans
  • Female
  • Cross-Sectional Studies
  • Cardiovascular System & Hematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chua, J., Chin, C. W. L., Hong, J., Chee, M. L., Le, T.-T., Ting, D. S. W., … Schmetterer, L. (2019). Impact of hypertension on retinal capillary microvasculature using optical coherence tomographic angiography. J Hypertens, 37(3), 572–580. https://doi.org/10.1097/HJH.0000000000001916
Chua, Jacqueline, Calvin Woon Loong Chin, Jimmy Hong, Miao Li Chee, Thu-Thao Le, Daniel Shu Wei Ting, Tien Yin Wong, and Leopold Schmetterer. “Impact of hypertension on retinal capillary microvasculature using optical coherence tomographic angiography.J Hypertens 37, no. 3 (March 2019): 572–80. https://doi.org/10.1097/HJH.0000000000001916.
Chua J, Chin CWL, Hong J, Chee ML, Le T-T, Ting DSW, et al. Impact of hypertension on retinal capillary microvasculature using optical coherence tomographic angiography. J Hypertens. 2019 Mar;37(3):572–80.
Chua, Jacqueline, et al. “Impact of hypertension on retinal capillary microvasculature using optical coherence tomographic angiography.J Hypertens, vol. 37, no. 3, Mar. 2019, pp. 572–80. Pubmed, doi:10.1097/HJH.0000000000001916.
Chua J, Chin CWL, Hong J, Chee ML, Le T-T, Ting DSW, Wong TY, Schmetterer L. Impact of hypertension on retinal capillary microvasculature using optical coherence tomographic angiography. J Hypertens. 2019 Mar;37(3):572–580.

Published In

J Hypertens

DOI

EISSN

1473-5598

Publication Date

March 2019

Volume

37

Issue

3

Start / End Page

572 / 580

Location

Netherlands

Related Subject Headings

  • Tomography, Optical Coherence
  • Retinal Vessels
  • Middle Aged
  • Microvessels
  • Male
  • Hypertension
  • Humans
  • Female
  • Cross-Sectional Studies
  • Cardiovascular System & Hematology