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A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation.

Publication ,  Journal Article
Luo, X; Ikeda, Y; Parker, KL
Published in: Cell
May 20, 1994

Studies in adrenocortical cells have implicated the orphan nuclear receptor SF-1 in the gene regulation of the steroid hydroxylases. We used targeted disruption of the Ftz-F1 gene, which encodes SF-1, to examine its role in intact mice. Despite normal survival in utero, all Ftz-F1 null animals died by postnatal day 8; these animals lacked adrenal glands and gonads and were severely deficient in corticosterone, supporting adrenocortical insufficiency as the probable cause of death. Male and female Ftz-F1 null mice had female internal genitalia, despite complete gonadal agenesis. These studies establish that the Ftz-F1 gene is essential for sexual differentiation and formation of the primary steroidogenic tissues.

Duke Scholars

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Published In

Cell

DOI

ISSN

0092-8674

Publication Date

May 20, 1994

Volume

77

Issue

4

Start / End Page

481 / 490

Location

United States

Related Subject Headings

  • Transcription Factors
  • Steroidogenic Factor 1
  • Sex Differentiation
  • Receptors, Cytoplasmic and Nuclear
  • Molecular Sequence Data
  • Mice, Knockout
  • Mice
  • Male
  • Homeodomain Proteins
  • Gonads
 

Citation

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Luo, X., Ikeda, Y., & Parker, K. L. (1994). A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell, 77(4), 481–490. https://doi.org/10.1016/0092-8674(94)90211-9
Luo, X., Y. Ikeda, and K. L. Parker. “A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation.Cell 77, no. 4 (May 20, 1994): 481–90. https://doi.org/10.1016/0092-8674(94)90211-9.
Luo, X., et al. “A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation.Cell, vol. 77, no. 4, May 1994, pp. 481–90. Pubmed, doi:10.1016/0092-8674(94)90211-9.
Journal cover image

Published In

Cell

DOI

ISSN

0092-8674

Publication Date

May 20, 1994

Volume

77

Issue

4

Start / End Page

481 / 490

Location

United States

Related Subject Headings

  • Transcription Factors
  • Steroidogenic Factor 1
  • Sex Differentiation
  • Receptors, Cytoplasmic and Nuclear
  • Molecular Sequence Data
  • Mice, Knockout
  • Mice
  • Male
  • Homeodomain Proteins
  • Gonads