A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation.
Publication
, Journal Article
Luo, X; Ikeda, Y; Parker, KL
Published in: Cell
May 20, 1994
Studies in adrenocortical cells have implicated the orphan nuclear receptor SF-1 in the gene regulation of the steroid hydroxylases. We used targeted disruption of the Ftz-F1 gene, which encodes SF-1, to examine its role in intact mice. Despite normal survival in utero, all Ftz-F1 null animals died by postnatal day 8; these animals lacked adrenal glands and gonads and were severely deficient in corticosterone, supporting adrenocortical insufficiency as the probable cause of death. Male and female Ftz-F1 null mice had female internal genitalia, despite complete gonadal agenesis. These studies establish that the Ftz-F1 gene is essential for sexual differentiation and formation of the primary steroidogenic tissues.
Duke Scholars
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Published In
Cell
DOI
ISSN
0092-8674
Publication Date
May 20, 1994
Volume
77
Issue
4
Start / End Page
481 / 490
Location
United States
Related Subject Headings
- Transcription Factors
- Steroidogenic Factor 1
- Sex Differentiation
- Receptors, Cytoplasmic and Nuclear
- Molecular Sequence Data
- Mice, Knockout
- Mice
- Male
- Homeodomain Proteins
- Gonads
Citation
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Chicago
ICMJE
MLA
NLM
Luo, X., Ikeda, Y., & Parker, K. L. (1994). A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell, 77(4), 481–490. https://doi.org/10.1016/0092-8674(94)90211-9
Luo, X., Y. Ikeda, and K. L. Parker. “A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation.” Cell 77, no. 4 (May 20, 1994): 481–90. https://doi.org/10.1016/0092-8674(94)90211-9.
Luo X, Ikeda Y, Parker KL. A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell. 1994 May 20;77(4):481–90.
Luo, X., et al. “A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation.” Cell, vol. 77, no. 4, May 1994, pp. 481–90. Pubmed, doi:10.1016/0092-8674(94)90211-9.
Luo X, Ikeda Y, Parker KL. A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell. 1994 May 20;77(4):481–490.
Published In
Cell
DOI
ISSN
0092-8674
Publication Date
May 20, 1994
Volume
77
Issue
4
Start / End Page
481 / 490
Location
United States
Related Subject Headings
- Transcription Factors
- Steroidogenic Factor 1
- Sex Differentiation
- Receptors, Cytoplasmic and Nuclear
- Molecular Sequence Data
- Mice, Knockout
- Mice
- Male
- Homeodomain Proteins
- Gonads