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A cell-specific nuclear receptor plays essential roles in adrenal and gonadal development.

Publication ,  Journal Article
Luo, X; Ikeda, Y; Lala, DS; Baity, LA; Meade, JC; Parker, KL
Published in: Endocr Res
1995

Recent analyses of the cytochrome P450 steroid hydroxylases have established a key role for an orphan nuclear receptor, designated steroidogenic factor 1 (SF-1), in their coordinate, cell-selective expression. SF-1 was proposed to regulate the steroid hydroxylases by interacting with shared promoter elements in their 5'-flanking regions. During mouse embryonic development, SF-1 was expressed from the earliest stages of organogenesis of the steroidogenic tissues, suggesting a key role in steroidogenic cell differentiation. Finally, disruption of the gene encoding SF-1 revealed its essential function in the development of the adrenal glands and gonads and in pituitary gonadotrope function. These studies suggest that SF-1 acts at multiple levels of the reproductive axis to maintain reproductive competence.

Duke Scholars

Published In

Endocr Res

DOI

ISSN

0743-5800

Publication Date

1995

Volume

21

Issue

1-2

Start / End Page

517 / 524

Location

England

Related Subject Headings

  • Transcription Factors
  • Steroidogenic Factor 1
  • Receptors, Cytoplasmic and Nuclear
  • Mice, Knockout
  • Mice
  • Male
  • Insect Proteins
  • Hypothalamo-Hypophyseal System
  • Homeodomain Proteins
  • Gonads
 

Citation

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MLA
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Luo, X., Ikeda, Y., Lala, D. S., Baity, L. A., Meade, J. C., & Parker, K. L. (1995). A cell-specific nuclear receptor plays essential roles in adrenal and gonadal development. Endocr Res, 21(1–2), 517–524. https://doi.org/10.3109/07435809509030469
Luo, X., Y. Ikeda, D. S. Lala, L. A. Baity, J. C. Meade, and K. L. Parker. “A cell-specific nuclear receptor plays essential roles in adrenal and gonadal development.Endocr Res 21, no. 1–2 (1995): 517–24. https://doi.org/10.3109/07435809509030469.
Luo X, Ikeda Y, Lala DS, Baity LA, Meade JC, Parker KL. A cell-specific nuclear receptor plays essential roles in adrenal and gonadal development. Endocr Res. 1995;21(1–2):517–24.
Luo, X., et al. “A cell-specific nuclear receptor plays essential roles in adrenal and gonadal development.Endocr Res, vol. 21, no. 1–2, 1995, pp. 517–24. Pubmed, doi:10.3109/07435809509030469.
Luo X, Ikeda Y, Lala DS, Baity LA, Meade JC, Parker KL. A cell-specific nuclear receptor plays essential roles in adrenal and gonadal development. Endocr Res. 1995;21(1–2):517–524.
Journal cover image

Published In

Endocr Res

DOI

ISSN

0743-5800

Publication Date

1995

Volume

21

Issue

1-2

Start / End Page

517 / 524

Location

England

Related Subject Headings

  • Transcription Factors
  • Steroidogenic Factor 1
  • Receptors, Cytoplasmic and Nuclear
  • Mice, Knockout
  • Mice
  • Male
  • Insect Proteins
  • Hypothalamo-Hypophyseal System
  • Homeodomain Proteins
  • Gonads