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The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus.

Publication ,  Journal Article
Ikeda, Y; Luo, X; Abbud, R; Nilson, JH; Parker, KL
Published in: Mol Endocrinol
April 1995

The nuclear receptor steroidogenic factor 1 (SF-1) regulates the biosynthesis of the two essential mediators of male sexual differentiation, androgens and Müllerian-inhibiting substance, and is required for adrenal and gonadal development and gonadotropin expression. SF-1 is also expressed in the embryonic ventral diencephalon, subsequently localizing to the ventromedial hypothalamic nucleus, a region important for reproductive behavior. Mice lacking SF-1 secondary to targeted disruption of the Ftz-F1 gene had normal numbers and location of GnRH neurons but exhibited grossly impaired ventromedial hypothalamic nucleus structure. Despite their apparently normal GnRH neurons, treatment of Ftz-F1-disrupted mice with GnRH restored pituitary gonadotropin expression. These studies define SF-1's essential role within a discrete hypothalamic nucleus previously linked to reproduction.

Duke Scholars

Published In

Mol Endocrinol

DOI

ISSN

0888-8809

Publication Date

April 1995

Volume

9

Issue

4

Start / End Page

478 / 486

Location

United States

Related Subject Headings

  • Ventromedial Hypothalamic Nucleus
  • Transcription Factors
  • Steroidogenic Factor 1
  • Sex Differentiation
  • Receptors, LHRH
  • Receptors, Cytoplasmic and Nuclear
  • Neurons
  • Mice, Knockout
  • Mice
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Ikeda, Y., Luo, X., Abbud, R., Nilson, J. H., & Parker, K. L. (1995). The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus. Mol Endocrinol, 9(4), 478–486. https://doi.org/10.1210/mend.9.4.7659091
Ikeda, Y., X. Luo, R. Abbud, J. H. Nilson, and K. L. Parker. “The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus.Mol Endocrinol 9, no. 4 (April 1995): 478–86. https://doi.org/10.1210/mend.9.4.7659091.
Ikeda Y, Luo X, Abbud R, Nilson JH, Parker KL. The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus. Mol Endocrinol. 1995 Apr;9(4):478–86.
Ikeda, Y., et al. “The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus.Mol Endocrinol, vol. 9, no. 4, Apr. 1995, pp. 478–86. Pubmed, doi:10.1210/mend.9.4.7659091.
Ikeda Y, Luo X, Abbud R, Nilson JH, Parker KL. The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus. Mol Endocrinol. 1995 Apr;9(4):478–486.

Published In

Mol Endocrinol

DOI

ISSN

0888-8809

Publication Date

April 1995

Volume

9

Issue

4

Start / End Page

478 / 486

Location

United States

Related Subject Headings

  • Ventromedial Hypothalamic Nucleus
  • Transcription Factors
  • Steroidogenic Factor 1
  • Sex Differentiation
  • Receptors, LHRH
  • Receptors, Cytoplasmic and Nuclear
  • Neurons
  • Mice, Knockout
  • Mice
  • Male