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Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions.

Publication ,  Journal Article
Heffley, W; Song, EY; Xu, Z; Taylor, BN; Hughes, MA; McKinney, A; Joshua, M; Hull, C
Published in: Nat Neurosci
October 2018

The prevailing model of cerebellar learning states that climbing fibers (CFs) are both driven by, and serve to correct, erroneous motor output. However, this model is grounded largely in studies of behaviors that utilize hardwired neural pathways to link sensory input to motor output. To test whether this model applies to more flexible learning regimes that require arbitrary sensorimotor associations, we developed a cerebellar-dependent motor learning task that is compatible with both mesoscale and single-dendrite-resolution calcium imaging in mice. We found that CFs were preferentially driven by and more time-locked to correctly executed movements and other task parameters that predict reward outcome, exhibiting widespread correlated activity in parasagittal processing zones that was governed by these predictions. Together, our data suggest that such CF activity patterns are well-suited to drive learning by providing predictive instructional input that is consistent with an unsigned reinforcement learning signal but does not rely exclusively on motor errors.

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Published In

Nat Neurosci

DOI

EISSN

1546-1726

Publication Date

October 2018

Volume

21

Issue

10

Start / End Page

1431 / 1441

Location

United States

Related Subject Headings

  • Synaptic Transmission
  • Reaction Time
  • Pyrazines
  • Principal Component Analysis
  • Neuropeptides
  • Neurons
  • Neurology & Neurosurgery
  • Neural Pathways
  • Nerve Fibers
  • Motor Activity
 

Citation

APA
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ICMJE
MLA
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Heffley, W., Song, E. Y., Xu, Z., Taylor, B. N., Hughes, M. A., McKinney, A., … Hull, C. (2018). Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions. Nat Neurosci, 21(10), 1431–1441. https://doi.org/10.1038/s41593-018-0228-8
Heffley, William, Eun Young Song, Ziye Xu, Benjamin N. Taylor, Mary Anne Hughes, Andrew McKinney, Mati Joshua, and Court Hull. “Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions.Nat Neurosci 21, no. 10 (October 2018): 1431–41. https://doi.org/10.1038/s41593-018-0228-8.
Heffley W, Song EY, Xu Z, Taylor BN, Hughes MA, McKinney A, et al. Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions. Nat Neurosci. 2018 Oct;21(10):1431–41.
Heffley, William, et al. “Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions.Nat Neurosci, vol. 21, no. 10, Oct. 2018, pp. 1431–41. Pubmed, doi:10.1038/s41593-018-0228-8.
Heffley W, Song EY, Xu Z, Taylor BN, Hughes MA, McKinney A, Joshua M, Hull C. Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions. Nat Neurosci. 2018 Oct;21(10):1431–1441.

Published In

Nat Neurosci

DOI

EISSN

1546-1726

Publication Date

October 2018

Volume

21

Issue

10

Start / End Page

1431 / 1441

Location

United States

Related Subject Headings

  • Synaptic Transmission
  • Reaction Time
  • Pyrazines
  • Principal Component Analysis
  • Neuropeptides
  • Neurons
  • Neurology & Neurosurgery
  • Neural Pathways
  • Nerve Fibers
  • Motor Activity