
The importance of preclinical diagnostics in Parkinson disease.
Given the increasing recognition that neurodegeneration begins decades before the appearance of motor symptoms of Parkinson disease (PD), recent attention has turned to methods of preclinical or prodromal diagnosis. Accurate preclinical diagnosis of individuals at high risk of developing manifest motor PD can improve clinical counseling as well as provide an enriched cohort for studies of possible disease-modifying therapies. In this review article, the authors synthesize the myriad clinical, radiographic, and biochemical signatures of preclinical PD, with an emphasis on biomarkers that may provide accurate population screening for the disease. As individual biomarkers have relatively lowsensitivity and specificity, any population-based approach to preclinical diagnosis will likely combine multiple biomarkers to improve both negative and positive predictive value.
Duke Scholars
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Related Subject Headings
- Prodromal Symptoms
- Parkinson Disease
- Neurology & Neurosurgery
- Humans
- Early Diagnosis
- 5202 Biological psychology
- 3209 Neurosciences
- 3202 Clinical sciences
- 1702 Cognitive Sciences
- 1103 Clinical Sciences
Citation

Published In
DOI
EISSN
Publication Date
Volume
Start / End Page
Location
Related Subject Headings
- Prodromal Symptoms
- Parkinson Disease
- Neurology & Neurosurgery
- Humans
- Early Diagnosis
- 5202 Biological psychology
- 3209 Neurosciences
- 3202 Clinical sciences
- 1702 Cognitive Sciences
- 1103 Clinical Sciences