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A subcortical circuit linking the cerebellum to the basal ganglia engaged in vocal learning

Publication ,  Journal Article
Pidoux, L; Le Blanc, P; Levenes, C; Leblois, A
Published in: eLife
July 25, 2018

Speech is a complex sensorimotor skill, and vocal learning involves both the basal ganglia and the cerebellum. These subcortical structures interact indirectly through their respective loops with thalamo-cortical and brainstem networks, and directly via subcortical pathways, but the role of their interaction during sensorimotor learning remains undetermined. While songbirds and their song-dedicated basal ganglia-thalamo-cortical circuitry offer a unique opportunity to study subcortical circuits involved in vocal learning, the cerebellar contribution to avian song learning remains unknown. We demonstrate that the cerebellum provides a strong input to the song-related basal ganglia nucleus in zebra finches. Cerebellar signals are transmitted to the basal ganglia via a disynaptic connection through the thalamus and then conveyed to their cortical target and to the premotor nucleus controlling song production. Finally, cerebellar lesions impair juvenile song learning, opening new opportunities to investigate how subcortical interactions between the cerebellum and basal ganglia contribute to sensorimotor learning.

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Published In

eLife

DOI

EISSN

2050-084X

Publication Date

July 25, 2018

Volume

7

Publisher

eLife Sciences Publications, Ltd

Related Subject Headings

  • 0601 Biochemistry and Cell Biology
 

Citation

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Pidoux, L., Le Blanc, P., Levenes, C., & Leblois, A. (2018). A subcortical circuit linking the cerebellum to the basal ganglia engaged in vocal learning. ELife, 7. https://doi.org/10.7554/elife.32167
Pidoux, Ludivine, Pascale Le Blanc, Carole Levenes, and Arthur Leblois. “A subcortical circuit linking the cerebellum to the basal ganglia engaged in vocal learning.” ELife 7 (July 25, 2018). https://doi.org/10.7554/elife.32167.
Pidoux L, Le Blanc P, Levenes C, Leblois A. A subcortical circuit linking the cerebellum to the basal ganglia engaged in vocal learning. eLife. 2018 Jul 25;7.
Pidoux, Ludivine, et al. “A subcortical circuit linking the cerebellum to the basal ganglia engaged in vocal learning.” ELife, vol. 7, eLife Sciences Publications, Ltd, July 2018. Crossref, doi:10.7554/elife.32167.
Pidoux L, Le Blanc P, Levenes C, Leblois A. A subcortical circuit linking the cerebellum to the basal ganglia engaged in vocal learning. eLife. eLife Sciences Publications, Ltd; 2018 Jul 25;7.

Published In

eLife

DOI

EISSN

2050-084X

Publication Date

July 25, 2018

Volume

7

Publisher

eLife Sciences Publications, Ltd

Related Subject Headings

  • 0601 Biochemistry and Cell Biology