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CXCR4 expression predicts patient outcome and recurrence patterns after hepatic resection for colorectal liver metastases.

Publication ,  Journal Article
Yopp, AC; Shia, J; Butte, JM; Allen, PJ; Fong, Y; Jarnagin, WR; DeMatteo, RP; D'Angelica, MI
Published in: Ann Surg Oncol
July 2012

BACKGROUND: The purpose of this study was to determine if the expression of the chemokine receptors, CXCR4 and CCR7, and the chemokine ligand, CXCL12, in completely resected colorectal cancer hepatic metastases are predictive of disease-specific survival, recurrence-free survival and patterns of recurrence. METHODS: Immunohistochemical analysis of CXCR4, CCR7 and CXCL12 expression within resected hepatic metastases was performed and correlated with clinicopathological variables, disease-specific survival, recurrence-free survival and patterns of recurrence. RESULTS: Seventy-five patients who underwent partial hepatectomy with curative intent were studied. CXCR4 expression (hazard ratio [HR] 3.6, 95% confidence interval [95% CI] 1.4-9.1) and clinical risk score >2 (HR 2.3, 95% CI 1.1-4.7) were independently associated with disease-specific survival by multivariate analysis. The 5-year estimated disease-specific survival rates for positive and negative CXCR4 tumor expression were 44 and 77%, respectively (P = 0.005). CXCR4 expression (HR 2.2, 95% CI 1.2-4.2) and clinical risk score >2 (HR 1.9, 95% CI 1.1-3.4) were independently associated with recurrence-free survival by multivariate analysis. The five year estimated recurrence-free survival rates for positive and negative CXCR4 tumor expression were 20 and 50%, respectively (P = 0.004). Neither CXCL12 nor CCR7 expression in tumors predicted disease-specific survival or recurrence-free survival. Forty-nine patients (65%) developed recurrent disease after initial hepatectomy. Negative CXCR4 tumor expression was associated with favorable recurrence patterns amenable to salvage resection and/or ablation. CONCLUSIONS: Negative CXCR4 expression in resected colorectal cancer hepatic metastases is independently associated with improved disease-specific and recurrence-free survival and favorable patterns of recurrence.

Duke Scholars

Published In

Ann Surg Oncol

DOI

EISSN

1534-4681

Publication Date

July 2012

Volume

19 Suppl 3

Start / End Page

S339 / S346

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Receptors, CXCR4
  • Receptors, CCR7
  • Proportional Hazards Models
  • Predictive Value of Tests
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Multivariate Analysis
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yopp, A. C., Shia, J., Butte, J. M., Allen, P. J., Fong, Y., Jarnagin, W. R., … D’Angelica, M. I. (2012). CXCR4 expression predicts patient outcome and recurrence patterns after hepatic resection for colorectal liver metastases. Ann Surg Oncol, 19 Suppl 3, S339–S346. https://doi.org/10.1245/s10434-011-1774-4
Yopp, Adam C., Jinru Shia, Jean M. Butte, Peter J. Allen, Yuman Fong, William R. Jarnagin, Ronald P. DeMatteo, and Michael I. D’Angelica. “CXCR4 expression predicts patient outcome and recurrence patterns after hepatic resection for colorectal liver metastases.Ann Surg Oncol 19 Suppl 3 (July 2012): S339–46. https://doi.org/10.1245/s10434-011-1774-4.
Yopp AC, Shia J, Butte JM, Allen PJ, Fong Y, Jarnagin WR, et al. CXCR4 expression predicts patient outcome and recurrence patterns after hepatic resection for colorectal liver metastases. Ann Surg Oncol. 2012 Jul;19 Suppl 3:S339–46.
Yopp, Adam C., et al. “CXCR4 expression predicts patient outcome and recurrence patterns after hepatic resection for colorectal liver metastases.Ann Surg Oncol, vol. 19 Suppl 3, July 2012, pp. S339–46. Pubmed, doi:10.1245/s10434-011-1774-4.
Yopp AC, Shia J, Butte JM, Allen PJ, Fong Y, Jarnagin WR, DeMatteo RP, D’Angelica MI. CXCR4 expression predicts patient outcome and recurrence patterns after hepatic resection for colorectal liver metastases. Ann Surg Oncol. 2012 Jul;19 Suppl 3:S339–S346.
Journal cover image

Published In

Ann Surg Oncol

DOI

EISSN

1534-4681

Publication Date

July 2012

Volume

19 Suppl 3

Start / End Page

S339 / S346

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Receptors, CXCR4
  • Receptors, CCR7
  • Proportional Hazards Models
  • Predictive Value of Tests
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Multivariate Analysis
  • Middle Aged
  • Male