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Is port site resection necessary in the surgical management of gallbladder cancer?

Publication ,  Journal Article
Maker, AV; Butte, JM; Oxenberg, J; Kuk, D; Gonen, M; Fong, Y; Dematteo, RP; D'Angelica, MI; Allen, PJ; Jarnagin, WR
Published in: Ann Surg Oncol
February 2012

BACKGROUND: In selected patients with incidental gallbladder carcinoma (GBCA) diagnosed after laparoscopic cholecystectomy (LC), definitive resection is warranted. Port site excision has been advocated but remains controversial. METHODS: Patients with GBCA were identified through institutional/departmental databases. The subset of patients with incidental tumors identified after LC and submitted to definitive surgical therapy were selected. Those subjected to port site resection were compared with patients who underwent resection without port site removal and analyzed for differences in recurrence patterns and survival. RESULTS: From 1992 to 2009, 113 patients with incidental GBCA presented for definitive resection after LC; 69 patients had port site resection and 44 did not. In the resected port site group, depth of tumor invasion was T1b = 6, T2 = 35, T3 = 28, and 13 (19%) had port site metastases. Port site disease was seen only in patients with T2 or T3 tumors and correlated with the development of peritoneal metastases (P = 0.01). Median survival of patients with T2/T3 tumors without port site metastases was 42 months compared to 17 months in patients with port site disease (P = 0.005). When only R0 resected patients were compared and adjusted for T and N stage, port site resection was not associated with overall survival (P = 0.23) or recurrence-free survival (P = 0.69). CONCLUSIONS: In patients with incidental GBCA, port site metastases were associated with peritoneal disease and decreased survival. Port site resection was not associated with improved survival or disease recurrence and should not be considered mandatory during definitive surgical treatment.

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Published In

Ann Surg Oncol

DOI

EISSN

1534-4681

Publication Date

February 2012

Volume

19

Issue

2

Start / End Page

409 / 417

Location

United States

Related Subject Headings

  • Survival Rate
  • Reoperation
  • Prospective Studies
  • Prognosis
  • Peritoneal Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
 

Citation

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Maker, A. V., Butte, J. M., Oxenberg, J., Kuk, D., Gonen, M., Fong, Y., … Jarnagin, W. R. (2012). Is port site resection necessary in the surgical management of gallbladder cancer? Ann Surg Oncol, 19(2), 409–417. https://doi.org/10.1245/s10434-011-1850-9
Maker, Ajay V., Jean M. Butte, Jacqueline Oxenberg, Deborah Kuk, Mithat Gonen, Yuman Fong, Ronald P. Dematteo, Michael I. D’Angelica, Peter J. Allen, and William R. Jarnagin. “Is port site resection necessary in the surgical management of gallbladder cancer?Ann Surg Oncol 19, no. 2 (February 2012): 409–17. https://doi.org/10.1245/s10434-011-1850-9.
Maker AV, Butte JM, Oxenberg J, Kuk D, Gonen M, Fong Y, et al. Is port site resection necessary in the surgical management of gallbladder cancer? Ann Surg Oncol. 2012 Feb;19(2):409–17.
Maker, Ajay V., et al. “Is port site resection necessary in the surgical management of gallbladder cancer?Ann Surg Oncol, vol. 19, no. 2, Feb. 2012, pp. 409–17. Pubmed, doi:10.1245/s10434-011-1850-9.
Maker AV, Butte JM, Oxenberg J, Kuk D, Gonen M, Fong Y, Dematteo RP, D’Angelica MI, Allen PJ, Jarnagin WR. Is port site resection necessary in the surgical management of gallbladder cancer? Ann Surg Oncol. 2012 Feb;19(2):409–417.
Journal cover image

Published In

Ann Surg Oncol

DOI

EISSN

1534-4681

Publication Date

February 2012

Volume

19

Issue

2

Start / End Page

409 / 417

Location

United States

Related Subject Headings

  • Survival Rate
  • Reoperation
  • Prospective Studies
  • Prognosis
  • Peritoneal Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male