Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Contributions from surgeons to clinical trials and research on the management of soft tissue sarcoma.

Publication ,  Journal Article
Allen, PJ; Stojadinovic, A; Shriver, CD; Jaques, DP
Published in: Ann Surg Oncol
1998

BACKGROUND: Surgical resection is the primary treatment for soft tissue sarcoma. Surgeons are in a position to develop and define appropriate treatment strategies for this disease. In an effort to define the contributions of surgeons to the management of sarcoma, the surgical and clinical oncology literature from January 1983 through June 1996 was reviewed. METHODS: A computerized literature search of the Cancerlit database for January 1983 to June 1996 was performed. The search was limited to the topic of soft tissue sarcoma and was further confined to 15 journals that publish articles relevant to surgical management. These studies were then categorized by multiple parameters and analyzed. RESULTS: The Cancerlit file contained 4478 articles in which sarcoma was the primary topic. When the search was limited to 15 journals frequently read by surgeons, 479 references (11%) were retrieved. Within the surgical literature, 95 of the 479 articles (20%) described prospective studies, of which 33 were prospective and randomized. These studies represent all but three of the prospective randomized trials within the literature during the time period reviewed. The management of patients with sarcoma was evaluated in 26 of the prospective randomized trials; of these, 13 trials evaluated adjuvant chemotherapy, three evaluated adjuvant radiotherapy, and ten evaluated the chemotherapeutic treatment of metastatic disease. Surgical oncologists were the first or senior author on 10 of the 16 prospective randomized studies regarding adjuvant radiation or chemotherapy. Four of the 16 trials evaluating adjuvant therapy contained more than 100 patients, and three of those four were from cooperative group efforts. All but one of the studies of adjuvant therapy with less than 100 patients were from single institutional trials. CONCLUSIONS: Although the surgical and clinical oncology literature on soft tissue sarcoma is composed primarily of retrospective reviews, the prospective randomized trials reported represent almost all of the randomized trials in the literature and have significant contributions from surgeons. Surgeons can guide and design clinical trials, but overall patient accrual as represented by soft tissue sarcoma is low, and may be improved through cooperative group efforts.

Duke Scholars

Published In

Ann Surg Oncol

DOI

ISSN

1068-9265

Publication Date

1998

Volume

5

Issue

5

Start / End Page

437 / 441

Location

United States

Related Subject Headings

  • Soft Tissue Neoplasms
  • Sarcoma
  • Research
  • Randomized Controlled Trials as Topic
  • Oncology & Carcinogenesis
  • Medical Oncology
  • Humans
  • General Surgery
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Allen, P. J., Stojadinovic, A., Shriver, C. D., & Jaques, D. P. (1998). Contributions from surgeons to clinical trials and research on the management of soft tissue sarcoma. Ann Surg Oncol, 5(5), 437–441. https://doi.org/10.1007/BF02303862
Allen, P. J., A. Stojadinovic, C. D. Shriver, and D. P. Jaques. “Contributions from surgeons to clinical trials and research on the management of soft tissue sarcoma.Ann Surg Oncol 5, no. 5 (1998): 437–41. https://doi.org/10.1007/BF02303862.
Allen PJ, Stojadinovic A, Shriver CD, Jaques DP. Contributions from surgeons to clinical trials and research on the management of soft tissue sarcoma. Ann Surg Oncol. 1998;5(5):437–41.
Allen, P. J., et al. “Contributions from surgeons to clinical trials and research on the management of soft tissue sarcoma.Ann Surg Oncol, vol. 5, no. 5, 1998, pp. 437–41. Pubmed, doi:10.1007/BF02303862.
Allen PJ, Stojadinovic A, Shriver CD, Jaques DP. Contributions from surgeons to clinical trials and research on the management of soft tissue sarcoma. Ann Surg Oncol. 1998;5(5):437–441.
Journal cover image

Published In

Ann Surg Oncol

DOI

ISSN

1068-9265

Publication Date

1998

Volume

5

Issue

5

Start / End Page

437 / 441

Location

United States

Related Subject Headings

  • Soft Tissue Neoplasms
  • Sarcoma
  • Research
  • Randomized Controlled Trials as Topic
  • Oncology & Carcinogenesis
  • Medical Oncology
  • Humans
  • General Surgery
  • 1112 Oncology and Carcinogenesis