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BRCA germline mutations in Jewish patients with pancreatic adenocarcinoma.

Publication ,  Journal Article
Ferrone, CR; Levine, DA; Tang, LH; Allen, PJ; Jarnagin, W; Brennan, MF; Offit, K; Robson, ME
Published in: J Clin Oncol
January 20, 2009

PURPOSE: The prognostic significance of germline BRCA1 and BRCA2 mutations in Jewish patients with pancreatic adenocarcinoma (PAC) is unknown. Our objective was to define the prevalence of BRCA1 and BRCA2 in an unselected group of Jewish patients and to compare the clinical characteristics and overall survival (OS) of patients with resected BRCA mutation-associated PAC to PAC patients without mutations. PATIENTS AND METHODS: Jewish patients with PAC resected between January 1986 and January 2004 were identified. DNA was extracted from the archived material, anonymized, and genotyped for founder mutations in BRCA1 (185delAG, 5382insC) and BRCA2 (6174delT). Standard two-sided statistical tests were utilized. RESULTS: Of the 187 Jewish patients who underwent resection for PAC, tissue was available for 145 patients. Eight subjects (5.5%) had a BRCA founder mutation (two with BRCA1 [1.3%], six with BRCA2 [4.1%]). The BRCA2 founder mutation was identified in 4.1% of patients with pancreatic adenocarcinoma compared with only 1.1% of cancer-free Washington, DC,-area controls (4.1% v 1.1%; P = .007; odds ratio, 3.85; 95% CI, 2.1 to 10.8). Patients with and without BRCA1 or BRCA2 mutations did not differ in age (mean, 66 v 73 years; P = .6) or other clinicopathologic features. OS was not significantly different (median, 6 v 16 months; P = .35). A previous cancer was reported by 24% (35 of 145) of patients with the most common sites being breast cancer (9 of 35; 74%) and prostate cancer (8 of 35; 23%). CONCLUSION: Founder mutations for BRCA1 and BRCA2 were identified in 5.5% of Ashkenazi patients operated on for PAC. BRCA2 mutations were more prevalent than documented by population studies. Consistent with previous reports, BRCA2 mutations are associated with an increased risk of PAC.

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Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

January 20, 2009

Volume

27

Issue

3

Start / End Page

433 / 438

Location

United States

Related Subject Headings

  • Pancreatic Neoplasms
  • Oncology & Carcinogenesis
  • Mutation
  • Middle Aged
  • Male
  • Jews
  • Humans
  • Genes, BRCA2
  • Genes, BRCA1
  • Founder Effect
 

Citation

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ICMJE
MLA
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Ferrone, C. R., Levine, D. A., Tang, L. H., Allen, P. J., Jarnagin, W., Brennan, M. F., … Robson, M. E. (2009). BRCA germline mutations in Jewish patients with pancreatic adenocarcinoma. J Clin Oncol, 27(3), 433–438. https://doi.org/10.1200/JCO.2008.18.5546
Ferrone, Cristina R., Douglas A. Levine, Laura H. Tang, Peter J. Allen, William Jarnagin, Murray F. Brennan, Kenneth Offit, and Mark E. Robson. “BRCA germline mutations in Jewish patients with pancreatic adenocarcinoma.J Clin Oncol 27, no. 3 (January 20, 2009): 433–38. https://doi.org/10.1200/JCO.2008.18.5546.
Ferrone CR, Levine DA, Tang LH, Allen PJ, Jarnagin W, Brennan MF, et al. BRCA germline mutations in Jewish patients with pancreatic adenocarcinoma. J Clin Oncol. 2009 Jan 20;27(3):433–8.
Ferrone, Cristina R., et al. “BRCA germline mutations in Jewish patients with pancreatic adenocarcinoma.J Clin Oncol, vol. 27, no. 3, Jan. 2009, pp. 433–38. Pubmed, doi:10.1200/JCO.2008.18.5546.
Ferrone CR, Levine DA, Tang LH, Allen PJ, Jarnagin W, Brennan MF, Offit K, Robson ME. BRCA germline mutations in Jewish patients with pancreatic adenocarcinoma. J Clin Oncol. 2009 Jan 20;27(3):433–438.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

January 20, 2009

Volume

27

Issue

3

Start / End Page

433 / 438

Location

United States

Related Subject Headings

  • Pancreatic Neoplasms
  • Oncology & Carcinogenesis
  • Mutation
  • Middle Aged
  • Male
  • Jews
  • Humans
  • Genes, BRCA2
  • Genes, BRCA1
  • Founder Effect