Skip to main content
Journal cover image

Longitudinal evaluation of quality of life in Laryngeal Cancer patients treated with surgery.

Publication ,  Journal Article
Bui, AT; Yong Ji, KS; Pham, CT; Le, KM; Tong, TX; Lee, WT
Published in: Int J Surg
October 2018

BACKGROUND: There is insufficient prospective data on quality of life outcomes for laryngeal cancer patients undergoing surgery, especially in low- and middle-income countries. This limits clinical and patient decision-making, and survivorship expectations. This research aimed to define longitudinal changes in quality of life in patients with laryngeal cancer from the pre-operative to post-operative period. MATERIALS AND METHODS: A prospective cohort with primary laryngeal cancer treated with standard-of-care surgery who have completed a minimum follow-up of 1 year were evaluated. Patients underwent one of three standard-of-care surgical treatments: transoral laser microsurgery, open partial laryngectomy and total laryngectomy. Patients completed the EORTC-C30 quality of life questionnaire and associated Head and Neck module (EORTC-H&N35) pre- and post-operatively at 1, 3, 6, and 12 months. Global, functional- and symptom-related domains were assessed. RESULTS: 140 patients participated in the study (135 males and 5 females, mean [SD] age 57.0 [7.8] years). Patients were grouped based on primary surgical treatment: (Group 1-transoral laser microsurgery; Group 2-open partial laryngectomy; Group 3-total laryngectomy). In Group 1, a significant decline at 3 months was reported in all five functional scales and five symptom scales: speech, social eating, cough, appetite, and fatigue. In Group 2, significant decline at 1 month post-operative period was seen in the global health scale, all five functional scales and six symptom scales: speech, social eating, cough, appetite, sexuality, and feeling ill. In Group 3, significant decline without return to baseline was seen in the global health scale, all five functional scales and six symptom scales: speech, sense, cough, sticky saliva, sexuality, and social contact. These scores were lowest at 1 month post-op. CONCLUSIONS: Significant changes in quality of life domains after laryngeal cancer surgery were identified. This research provides critical information for improving clinical and patient decision-making and for informing survivorship expectations for those undergoing surgery for laryngeal cancer.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Int J Surg

DOI

EISSN

1743-9159

Publication Date

October 2018

Volume

58

Start / End Page

65 / 70

Location

United States

Related Subject Headings

  • Surgery
  • Quality of Life
  • Prospective Studies
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Laryngectomy
  • Laryngeal Neoplasms
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bui, A. T., Yong Ji, K. S., Pham, C. T., Le, K. M., Tong, T. X., & Lee, W. T. (2018). Longitudinal evaluation of quality of life in Laryngeal Cancer patients treated with surgery. Int J Surg, 58, 65–70. https://doi.org/10.1016/j.ijsu.2018.09.011
Bui, Anh The, Keven Seung Yong Ji, Canh Tuan Pham, Ky Minh Le, Thang Xuan Tong, and Walter Tsong Lee. “Longitudinal evaluation of quality of life in Laryngeal Cancer patients treated with surgery.Int J Surg 58 (October 2018): 65–70. https://doi.org/10.1016/j.ijsu.2018.09.011.
Bui AT, Yong Ji KS, Pham CT, Le KM, Tong TX, Lee WT. Longitudinal evaluation of quality of life in Laryngeal Cancer patients treated with surgery. Int J Surg. 2018 Oct;58:65–70.
Bui, Anh The, et al. “Longitudinal evaluation of quality of life in Laryngeal Cancer patients treated with surgery.Int J Surg, vol. 58, Oct. 2018, pp. 65–70. Pubmed, doi:10.1016/j.ijsu.2018.09.011.
Bui AT, Yong Ji KS, Pham CT, Le KM, Tong TX, Lee WT. Longitudinal evaluation of quality of life in Laryngeal Cancer patients treated with surgery. Int J Surg. 2018 Oct;58:65–70.
Journal cover image

Published In

Int J Surg

DOI

EISSN

1743-9159

Publication Date

October 2018

Volume

58

Start / End Page

65 / 70

Location

United States

Related Subject Headings

  • Surgery
  • Quality of Life
  • Prospective Studies
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Laryngectomy
  • Laryngeal Neoplasms
  • Humans
  • Female