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Risk of Incident Cardiovascular Disease and Cardiovascular Risk Factors in First and Second-Generation Indians: The Singapore Indian Eye Study.

Publication ,  Journal Article
Gupta, P; Gan, ATL; Man, REK; Fenwick, EK; Tham, Y-C; Sabanayagam, C; Wong, TY; Cheng, C-Y; Lamoureux, EL
Published in: Sci Rep
October 4, 2018

Population-based data investigating generational differences in the risk of incident cardiovascular disease (CVD) and its risk determinants are rare. We examined the 6-year incidence of CVD and its risk factors in first- and second-generation ethnic Indians living in Singapore. 1749 participants (mean age [SD]: 55.5 [8.8] years; 47.5% male) from a population-based, longitudinal study of Indian adults were included for incident CVD outcome. Incident CVD was defined as self-reported myocardial infarction, angina pectoris or stroke which developed between baseline and follow-up. CVD-related risk factors included incident diabetes, hypertension, hyperlipidemia, obesity and chronic kidney disease (CKD). For incident CVD outcome, of the 1749 participants, 406 (23.2%) and 1343 (76.8%) were first and second-generation Indians, respectively. Of these, 73 (4.1%) reported incident CVD. In multivariable models, second-generation individuals had increased risk of developing CVD (RR = 2.04; 95% CI 1.04, 3.99; p = 0.038), hyperlipidemia (RR = 1.27; 95% CI 1.06, 1.53; p = 0.011), and CKD (RR = 1.92; 95% CI 1.22, 3.04; p = 0.005), compared to first-generation Indians. Second-generation Indians have increased risk of developing CVD and its associated risk factors such as hyperlipidemia and CKD compared to first-generation immigrants, independent of traditional CVD risk factors. More stratified and tailored CVD prevention strategies on second and subsequent generations of Indian immigrants in Singapore are warranted.

Duke Scholars

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

October 4, 2018

Volume

8

Issue

1

Start / End Page

14805

Location

England

Related Subject Headings

  • Singapore
  • Risk Factors
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Incidence
  • Humans
  • Female
  • Ethnicity
  • Cardiovascular Diseases
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gupta, P., Gan, A. T. L., Man, R. E. K., Fenwick, E. K., Tham, Y.-C., Sabanayagam, C., … Lamoureux, E. L. (2018). Risk of Incident Cardiovascular Disease and Cardiovascular Risk Factors in First and Second-Generation Indians: The Singapore Indian Eye Study. Sci Rep, 8(1), 14805. https://doi.org/10.1038/s41598-018-32833-0
Gupta, Preeti, Alfred Tau Liang Gan, Ryan Eyn Kidd Man, Eva K. Fenwick, Yih-Chung Tham, Charumathi Sabanayagam, Tien Yin Wong, Ching-Yu Cheng, and Ecosse L. Lamoureux. “Risk of Incident Cardiovascular Disease and Cardiovascular Risk Factors in First and Second-Generation Indians: The Singapore Indian Eye Study.Sci Rep 8, no. 1 (October 4, 2018): 14805. https://doi.org/10.1038/s41598-018-32833-0.
Gupta P, Gan ATL, Man REK, Fenwick EK, Tham Y-C, Sabanayagam C, et al. Risk of Incident Cardiovascular Disease and Cardiovascular Risk Factors in First and Second-Generation Indians: The Singapore Indian Eye Study. Sci Rep. 2018 Oct 4;8(1):14805.
Gupta, Preeti, et al. “Risk of Incident Cardiovascular Disease and Cardiovascular Risk Factors in First and Second-Generation Indians: The Singapore Indian Eye Study.Sci Rep, vol. 8, no. 1, Oct. 2018, p. 14805. Pubmed, doi:10.1038/s41598-018-32833-0.
Gupta P, Gan ATL, Man REK, Fenwick EK, Tham Y-C, Sabanayagam C, Wong TY, Cheng C-Y, Lamoureux EL. Risk of Incident Cardiovascular Disease and Cardiovascular Risk Factors in First and Second-Generation Indians: The Singapore Indian Eye Study. Sci Rep. 2018 Oct 4;8(1):14805.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

October 4, 2018

Volume

8

Issue

1

Start / End Page

14805

Location

England

Related Subject Headings

  • Singapore
  • Risk Factors
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Incidence
  • Humans
  • Female
  • Ethnicity
  • Cardiovascular Diseases