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Antenatal magnesium sulfate exposure and acute cardiorespiratory events in preterm infants.

Publication ,  Journal Article
De Jesus, LC; Sood, BG; Shankaran, S; Kendrick, D; Das, A; Bell, EF; Stoll, BJ; Laptook, AR; Walsh, MC; Carlo, WA; Sanchez, PJ; Van Meurs, KP ...
Published in: Am J Obstet Gynecol
January 2015

OBJECTIVE: Antenatal magnesium (anteMg) is used for various obstetric indications including fetal neuroprotection. Infants exposed to anteMg may be at risk for respiratory depression and delivery room (DR) resuscitation. The study objective was to compare the risk of acute cardiorespiratory events among preterm infants who were and were not exposed to anteMg. STUDY DESIGN: This was a retrospective analysis of prospective data collected in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network's Generic Database from April 1, 2011, through March 31, 2012. The primary outcome was DR intubation or respiratory support at birth or on day 1 of life. Secondary outcomes were invasive mechanical ventilation, hypotension treatment, neonatal morbidities, and mortality. Logistic regression analysis evaluated the risk of primary outcome after adjustment for covariates. RESULTS: We evaluated 1544 infants <29 weeks' gestational age (1091 in anteMg group and 453 in nonexposed group). Mothers in the anteMg group were more likely to have higher education, pregnancy-induced hypertension, and antenatal corticosteroids, while their infants were younger in gestation and weighed less (P < .05). The primary outcome (odds ratio [OR], 1.2; 95% confidence interval [CI], 0.88-1.65) was similar between groups. Hypotension treatment (OR, 0.70; 95% CI, 0.51-0.97) and invasive mechanical ventilation (OR, 0.54; 95% CI, 0.41-0.72) were significantly less in the anteMg group. CONCLUSION: Among preterm infants age <29 weeks' gestation, anteMg exposure was not associated with an increase in cardiorespiratory events in the early newborn period. The safety of anteMg as measured by the need for DR intubation or respiratory support on day 1 of life was comparable between groups.

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Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

January 2015

Volume

212

Issue

1

Start / End Page

94.e1 / 94.e7

Location

United States

Related Subject Headings

  • Young Adult
  • Retrospective Studies
  • Respiration Disorders
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Magnesium Sulfate
  • Infant, Premature, Diseases
  • Infant, Premature
  • Infant, Newborn
 

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De Jesus, L. C., Sood, B. G., Shankaran, S., Kendrick, D., Das, A., Bell, E. F., … Eunice Kennedy Shriver National Institute of Health and Human Development Neonatal Research Network, . (2015). Antenatal magnesium sulfate exposure and acute cardiorespiratory events in preterm infants. Am J Obstet Gynecol, 212(1), 94.e1-94.e7. https://doi.org/10.1016/j.ajog.2014.07.023
De Jesus, Lilia C., Beena G. Sood, Seetha Shankaran, Douglas Kendrick, Abhik Das, Edward F. Bell, Barbara J. Stoll, et al. “Antenatal magnesium sulfate exposure and acute cardiorespiratory events in preterm infants.Am J Obstet Gynecol 212, no. 1 (January 2015): 94.e1-94.e7. https://doi.org/10.1016/j.ajog.2014.07.023.
De Jesus LC, Sood BG, Shankaran S, Kendrick D, Das A, Bell EF, et al. Antenatal magnesium sulfate exposure and acute cardiorespiratory events in preterm infants. Am J Obstet Gynecol. 2015 Jan;212(1):94.e1-94.e7.
De Jesus, Lilia C., et al. “Antenatal magnesium sulfate exposure and acute cardiorespiratory events in preterm infants.Am J Obstet Gynecol, vol. 212, no. 1, Jan. 2015, pp. 94.e1-94.e7. Pubmed, doi:10.1016/j.ajog.2014.07.023.
De Jesus LC, Sood BG, Shankaran S, Kendrick D, Das A, Bell EF, Stoll BJ, Laptook AR, Walsh MC, Carlo WA, Sanchez PJ, Van Meurs KP, Bara R, Hale EC, Newman NS, Ball MB, Higgins RD, Eunice Kennedy Shriver National Institute of Health and Human Development Neonatal Research Network. Antenatal magnesium sulfate exposure and acute cardiorespiratory events in preterm infants. Am J Obstet Gynecol. 2015 Jan;212(1):94.e1-94.e7.
Journal cover image

Published In

Am J Obstet Gynecol

DOI

EISSN

1097-6868

Publication Date

January 2015

Volume

212

Issue

1

Start / End Page

94.e1 / 94.e7

Location

United States

Related Subject Headings

  • Young Adult
  • Retrospective Studies
  • Respiration Disorders
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Magnesium Sulfate
  • Infant, Premature, Diseases
  • Infant, Premature
  • Infant, Newborn