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Effect of vitamin D supplementation on cardiovascular risk in type 2 diabetes.

Publication ,  Journal Article
Angellotti, E; D'Alessio, D; Dawson-Hughes, B; Chu, Y; Nelson, J; Hu, P; Cohen, RM; Pittas, AG
Published in: Clin Nutr
October 2019

BACKGROUND & AIMS: Whether vitamin D affects lipid profile and cardiovascular disease (CVD) risk is controversial. We evaluated the effect of oral daily vitamin D supplementation on lipid profile and CVD risk in patients with well-controlled type 2 diabetes. METHODS: Secondary analysis in the vitamin D for established type 2 diabetes (DDM2) study, a double-blind, randomized, placebo-controlled clinical trial. 127 patients (mean age 60 years) with stable (HbA1c ≤ 7.5%) diabetes managed with lifestyle only or lifestyle plus metformin were randomized to receive 4000 IU/day of vitamin D3 (n = 66) or placebo (n = 61) for 48 weeks. Changes in lipid profile (total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides [TG] and TG/HDL ratio), C-reactive protein and CVD risk (calculated according the American College of Cardiology/American Heart Association [ACC/AHA] guidelines) were assessed at week 24 and 48. RESULTS: The mean [±SEM] plasma 25-hydroxyvitamin D [25(OH)D] level was higher in the vitamin D vs. the placebo group (20.5 ± 1.18 vs. -1.6 ± 1.2 ng/mL respectively; p < 0.001). There was no statistically significant change in lipid profile, C-reactive protein or CVD risk. Among patients who were not on cholesterol medication (n = 32), vitamin D supplementation reduced TG compared to placebo at week 48 (-18.74 ± 8.91 vs. 9.69 ± 8.60 mg/dL respectively; p = 0.032). CONCLUSION: One year supplementation with vitamin D3 at 4000 IU/day did not affect lipid profile, C-reactive protein and CVD risk in patients with stable type 2 diabetes not selected for vitamin D deficiency, with the exception of improvement of TG among patients not on cholesterol medication. REGISTRATION: ClinicalTrials.gov Identifier NCT01736865.

Duke Scholars

Published In

Clin Nutr

DOI

EISSN

1532-1983

Publication Date

October 2019

Volume

38

Issue

5

Start / End Page

2449 / 2453

Location

England

Related Subject Headings

  • Vitamin D
  • Nutrition & Dietetics
  • Middle Aged
  • Male
  • Lipids
  • Humans
  • Female
  • Dietary Supplements
  • Diabetes Mellitus, Type 2
  • Cardiovascular Diseases
 

Citation

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ICMJE
MLA
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Angellotti, E., D’Alessio, D., Dawson-Hughes, B., Chu, Y., Nelson, J., Hu, P., … Pittas, A. G. (2019). Effect of vitamin D supplementation on cardiovascular risk in type 2 diabetes. Clin Nutr, 38(5), 2449–2453. https://doi.org/10.1016/j.clnu.2018.10.003
Angellotti, Edith, David D’Alessio, Bess Dawson-Hughes, Yan Chu, Jason Nelson, Peter Hu, Robert M. Cohen, and Anastassios G. Pittas. “Effect of vitamin D supplementation on cardiovascular risk in type 2 diabetes.Clin Nutr 38, no. 5 (October 2019): 2449–53. https://doi.org/10.1016/j.clnu.2018.10.003.
Angellotti E, D’Alessio D, Dawson-Hughes B, Chu Y, Nelson J, Hu P, et al. Effect of vitamin D supplementation on cardiovascular risk in type 2 diabetes. Clin Nutr. 2019 Oct;38(5):2449–53.
Angellotti, Edith, et al. “Effect of vitamin D supplementation on cardiovascular risk in type 2 diabetes.Clin Nutr, vol. 38, no. 5, Oct. 2019, pp. 2449–53. Pubmed, doi:10.1016/j.clnu.2018.10.003.
Angellotti E, D’Alessio D, Dawson-Hughes B, Chu Y, Nelson J, Hu P, Cohen RM, Pittas AG. Effect of vitamin D supplementation on cardiovascular risk in type 2 diabetes. Clin Nutr. 2019 Oct;38(5):2449–2453.
Journal cover image

Published In

Clin Nutr

DOI

EISSN

1532-1983

Publication Date

October 2019

Volume

38

Issue

5

Start / End Page

2449 / 2453

Location

England

Related Subject Headings

  • Vitamin D
  • Nutrition & Dietetics
  • Middle Aged
  • Male
  • Lipids
  • Humans
  • Female
  • Dietary Supplements
  • Diabetes Mellitus, Type 2
  • Cardiovascular Diseases