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Steroidogenic factor 1: an essential mediator of endocrine development.

Publication ,  Journal Article
Parker, KL; Rice, DA; Lala, DS; Ikeda, Y; Luo, X; Wong, M; Bakke, M; Zhao, L; Frigeri, C; Hanley, NA; Stallings, N; Schimmer, BP
Published in: Recent Prog Horm Res
2002

The orphan nuclear receptor steroidogenic factor 1 (SF-1, also called Ad4BP and officially designated NR5A1) has emerged as an essential regulator of endocrine development and function. Initially identified as a tissue-specific transcriptional regulator of the cytochrome P450 steroid hydroxylases, SF-1 has considerably broader roles, as evidenced from studies in knockout mice lacking SF-1. The SF-1-knockout mice lacked adrenal glands and gonads and therefore died from adrenal insufficiency within the first week after birth. In addition, SF-1 knockout mice exhibited male-to-female sex reversal of their internal and external genitalia, impaired expression of multiple markers of pituitary gonadotropes, and agenesis of the ventromedial hypothalamic nucleus (VMH). These studies delineated essential roles of SF-I in regulating endocrine differentiation and function at multiple levels, particularly with respect to reproduction. This chapter will review the experiments that established SF-1 as a pivotal, global determinant of endocrine differentiation and function. We next discuss recent insights into the mechanisms controlling the expression and function of SF-1 as well as the current status of research aimed at delineating its roles in specific tissues. Finally, we highlight areas where additional studies are needed to expand our understanding of SF-1 action.

Duke Scholars

Published In

Recent Prog Horm Res

DOI

ISSN

0079-9963

Publication Date

2002

Volume

57

Start / End Page

19 / 36

Location

United States

Related Subject Headings

  • Transcription Factors
  • Steroidogenic Factor 1
  • Receptors, Cytoplasmic and Nuclear
  • Mutation
  • Mice, Knockout
  • Mice
  • Humans
  • Homeodomain Proteins
  • Gene Expression Regulation
  • Gene Expression
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Parker, K. L., Rice, D. A., Lala, D. S., Ikeda, Y., Luo, X., Wong, M., … Schimmer, B. P. (2002). Steroidogenic factor 1: an essential mediator of endocrine development. Recent Prog Horm Res, 57, 19–36. https://doi.org/10.1210/rp.57.1.19
Parker, Keith L., Douglas A. Rice, Deepak S. Lala, Yayoi Ikeda, Xunrong Luo, Margaret Wong, Marit Bakke, et al. “Steroidogenic factor 1: an essential mediator of endocrine development.Recent Prog Horm Res 57 (2002): 19–36. https://doi.org/10.1210/rp.57.1.19.
Parker KL, Rice DA, Lala DS, Ikeda Y, Luo X, Wong M, et al. Steroidogenic factor 1: an essential mediator of endocrine development. Recent Prog Horm Res. 2002;57:19–36.
Parker, Keith L., et al. “Steroidogenic factor 1: an essential mediator of endocrine development.Recent Prog Horm Res, vol. 57, 2002, pp. 19–36. Pubmed, doi:10.1210/rp.57.1.19.
Parker KL, Rice DA, Lala DS, Ikeda Y, Luo X, Wong M, Bakke M, Zhao L, Frigeri C, Hanley NA, Stallings N, Schimmer BP. Steroidogenic factor 1: an essential mediator of endocrine development. Recent Prog Horm Res. 2002;57:19–36.

Published In

Recent Prog Horm Res

DOI

ISSN

0079-9963

Publication Date

2002

Volume

57

Start / End Page

19 / 36

Location

United States

Related Subject Headings

  • Transcription Factors
  • Steroidogenic Factor 1
  • Receptors, Cytoplasmic and Nuclear
  • Mutation
  • Mice, Knockout
  • Mice
  • Humans
  • Homeodomain Proteins
  • Gene Expression Regulation
  • Gene Expression