Scholars@Duke publication: Prevention of allograft rejection by amplification of Foxp3(+)CD4(+)CD25(+) regulatory T cells.

Prevention of allograft rejection by amplification of Foxp3(+)CD4(+)CD25(+) regulatory T cells.

Publication , Journal Article

Xia, G; Shah, M; Luo, X

Published in: Transl Res

February 2009

CD4(+)CD25(+) T cells were identified originally as potent suppressors of autoimmunity and were later termed "natural regulatory T cells" or nTreg cells. Subsequently, a transcription factor called forkhead box protein 3 (Foxp3) was identified to be a critical regulator for Treg differentiation and function. Foxp3(+)CD4(+)CD25(+) Treg cells have been increasingly documented to suppress allograft rejection and to mediate allograft tolerance in transplantation. In this article, the authors review current approaches for amplification of allo-specific Foxp3(+)CD4(+)CD25(+) Treg cells for prevention of allograft rejection and induction of allo-specific transplant tolerance.

Duke Scholars

Author Xunrong Luo Medicine, Nephrology

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Published In

Transl Res

DOI

10.1016/j.trsl.2008.12.001

ISSN

1931-5244

Publication Date

February 2009

Volume

153

Issue

Start / End Page

60 / 70

Location

United States

Related Subject Headings

Transplantation, Homologous
T-Lymphocytes, Regulatory
Interleukin-2 Receptor alpha Subunit
Humans
Graft Rejection
General Clinical Medicine
Forkhead Transcription Factors
CD4 Antigens
3202 Clinical sciences
3101 Biochemistry and cell biology

Citation

APA

Chicago

ICMJE

MLA

NLM

Xia, G., Shah, M., & Luo, X. (2009). Prevention of allograft rejection by amplification of Foxp3(+)CD4(+)CD25(+) regulatory T cells. Transl Res, 153(2), 60–70. https://doi.org/10.1016/j.trsl.2008.12.001

Xia, Guliang, Malathi Shah, and Xunrong Luo. “Prevention of allograft rejection by amplification of Foxp3(+)CD4(+)CD25(+) regulatory T cells.” Transl Res 153, no. 2 (February 2009): 60–70. https://doi.org/10.1016/j.trsl.2008.12.001.

Xia G, Shah M, Luo X. Prevention of allograft rejection by amplification of Foxp3(+)CD4(+)CD25(+) regulatory T cells. Transl Res. 2009 Feb;153(2):60–70.

Xia, Guliang, et al. “Prevention of allograft rejection by amplification of Foxp3(+)CD4(+)CD25(+) regulatory T cells.” Transl Res, vol. 153, no. 2, Feb. 2009, pp. 60–70. Pubmed, doi:10.1016/j.trsl.2008.12.001.

Xia G, Shah M, Luo X. Prevention of allograft rejection by amplification of Foxp3(+)CD4(+)CD25(+) regulatory T cells. Transl Res. 2009 Feb;153(2):60–70.