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Histopathologic changes in anti-angiotensin II type 1 receptor antibody-positive kidney transplant recipients with acute rejection and no donor specific HLA antibodies.

Publication ,  Journal Article
Lim, MA; Palmer, M; Trofe-Clark, J; Bloom, RD; Jackson, A; Philogene, MC; Kamoun, M
Published in: Hum Immunol
April 2017

OBJECTIVE: To determine the association of antibodies against angiotensin II type 1 receptor (AT1R Ab) and histopathologic changes seen in patients with kidney allograft rejection and negative donor specific HLA antibodies (DSA). METHODS: Stored sera from 27 patients who had biopsy-proven rejection in the absence of DSA were tested for AT1R Ab. Biopsy slides of all patients were re-examined and classified according to Banff 2013 criteria. Histopathologic changes were compared between AT1R positive and negative patients. RESULTS: 75% of patients with positive pre-transplant AT1R Ab had antibody mediated rejection (AMR) compared to 37% of AT1R Ab-negative patients. A trend towards increased interstitial inflammation was observed in the AT1R Ab positive group (p=0.08). More patients in the AT1R Ab positive group had microcirculation inflammation (88% vs 58% with glomerulitis scores ≥1; 75% vs 58% with peritubular capillaritis scores ≥1). CONCLUSION: In kidney transplant recipients with rejection and no DSA, a higher incidence of AMR and worse inflammation scores are observed in the presence of positive pre-transplant AT1R antibodies.

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Published In

Hum Immunol

DOI

EISSN

1879-1166

Publication Date

April 2017

Volume

78

Issue

4

Start / End Page

350 / 356

Location

United States

Related Subject Headings

  • Vasculitis
  • Retrospective Studies
  • Receptor, Angiotensin, Type 1
  • Middle Aged
  • Male
  • Kidney Transplantation
  • Kidney
  • Isoantibodies
  • Incidence
  • Immunology
 

Citation

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MLA
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Lim, M. A., Palmer, M., Trofe-Clark, J., Bloom, R. D., Jackson, A., Philogene, M. C., & Kamoun, M. (2017). Histopathologic changes in anti-angiotensin II type 1 receptor antibody-positive kidney transplant recipients with acute rejection and no donor specific HLA antibodies. Hum Immunol, 78(4), 350–356. https://doi.org/10.1016/j.humimm.2017.03.004
Lim, Mary Ann, Matthew Palmer, Jennifer Trofe-Clark, Roy D. Bloom, Annette Jackson, Mary Carmelle Philogene, and Malek Kamoun. “Histopathologic changes in anti-angiotensin II type 1 receptor antibody-positive kidney transplant recipients with acute rejection and no donor specific HLA antibodies.Hum Immunol 78, no. 4 (April 2017): 350–56. https://doi.org/10.1016/j.humimm.2017.03.004.
Lim MA, Palmer M, Trofe-Clark J, Bloom RD, Jackson A, Philogene MC, et al. Histopathologic changes in anti-angiotensin II type 1 receptor antibody-positive kidney transplant recipients with acute rejection and no donor specific HLA antibodies. Hum Immunol. 2017 Apr;78(4):350–6.
Lim, Mary Ann, et al. “Histopathologic changes in anti-angiotensin II type 1 receptor antibody-positive kidney transplant recipients with acute rejection and no donor specific HLA antibodies.Hum Immunol, vol. 78, no. 4, Apr. 2017, pp. 350–56. Pubmed, doi:10.1016/j.humimm.2017.03.004.
Lim MA, Palmer M, Trofe-Clark J, Bloom RD, Jackson A, Philogene MC, Kamoun M. Histopathologic changes in anti-angiotensin II type 1 receptor antibody-positive kidney transplant recipients with acute rejection and no donor specific HLA antibodies. Hum Immunol. 2017 Apr;78(4):350–356.
Journal cover image

Published In

Hum Immunol

DOI

EISSN

1879-1166

Publication Date

April 2017

Volume

78

Issue

4

Start / End Page

350 / 356

Location

United States

Related Subject Headings

  • Vasculitis
  • Retrospective Studies
  • Receptor, Angiotensin, Type 1
  • Middle Aged
  • Male
  • Kidney Transplantation
  • Kidney
  • Isoantibodies
  • Incidence
  • Immunology