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Is home blood pressure variability itself an interventional target beyond lowering mean home blood pressure during anti-hypertensive treatment?

Publication ,  Journal Article
Hoshide, S; Yano, Y; Shimizu, M; Eguchi, K; Ishikawa, J; Kario, K
Published in: Hypertens Res
August 2012

It is unknown whether home blood pressure (BP) variability reduction is associated with target organ damage (TOD) protection independently of home mean BP reduction. We enrolled 310 hypertensive patients whose systolic BP (SBP) at home was over 135 mm Hg. The subjects measured their BP in the morning and evening for 7 days. In addition, we measured urinary albumin excretion (UAE) as a marker of TOD before and after 6 months of candesartan treatment (+thiazidediuretics). At baseline, UAE was associated with average home SBP (r=0.24, P<0.001), the s.d. of home SBP (r=0.15, P=0.011), and the maximum home SBP (r=0.27, P<0.001). During the intervention, significant reductions were found in average home SBP (146±13 vs. 132±12 mm Hg, P<0.001), s.d. of home SBP (12.9±4.8 vs. 11.8±4.4 mm Hg, P<0.001), and maximum home SBP (172.5±18.0 vs. 155.9±17.5 mm Hg, P<0.001). UAE levels were significantly reduced after 6 months of therapy compared with baseline (18.9 vs. 12.1 mg g(-1) Cre, P<0.001). In multiple regression analysis, the treatment-induced reduction in UAE was significantly associated with that of average home BP (P=0.003) but was not associated with that of s.d. of home SBP or that of maximum home SBP. Home BP variability is not itself an interventional target beyond lowering mean home BP during anti-hypertensive treatment.

Duke Scholars

Published In

Hypertens Res

DOI

EISSN

1348-4214

Publication Date

August 2012

Volume

35

Issue

8

Start / End Page

862 / 866

Location

England

Related Subject Headings

  • Treatment Outcome
  • Tetrazoles
  • Nephelometry and Turbidimetry
  • Middle Aged
  • Male
  • Linear Models
  • Hypertension
  • Humans
  • Female
  • Diuretics
 

Citation

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ICMJE
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Hoshide, S., Yano, Y., Shimizu, M., Eguchi, K., Ishikawa, J., & Kario, K. (2012). Is home blood pressure variability itself an interventional target beyond lowering mean home blood pressure during anti-hypertensive treatment? Hypertens Res, 35(8), 862–866. https://doi.org/10.1038/hr.2012.46
Hoshide, Satoshi, Yuichiro Yano, Motohiro Shimizu, Kazuo Eguchi, Joji Ishikawa, and Kazuomi Kario. “Is home blood pressure variability itself an interventional target beyond lowering mean home blood pressure during anti-hypertensive treatment?Hypertens Res 35, no. 8 (August 2012): 862–66. https://doi.org/10.1038/hr.2012.46.
Hoshide S, Yano Y, Shimizu M, Eguchi K, Ishikawa J, Kario K. Is home blood pressure variability itself an interventional target beyond lowering mean home blood pressure during anti-hypertensive treatment? Hypertens Res. 2012 Aug;35(8):862–6.
Hoshide, Satoshi, et al. “Is home blood pressure variability itself an interventional target beyond lowering mean home blood pressure during anti-hypertensive treatment?Hypertens Res, vol. 35, no. 8, Aug. 2012, pp. 862–66. Pubmed, doi:10.1038/hr.2012.46.
Hoshide S, Yano Y, Shimizu M, Eguchi K, Ishikawa J, Kario K. Is home blood pressure variability itself an interventional target beyond lowering mean home blood pressure during anti-hypertensive treatment? Hypertens Res. 2012 Aug;35(8):862–866.
Journal cover image

Published In

Hypertens Res

DOI

EISSN

1348-4214

Publication Date

August 2012

Volume

35

Issue

8

Start / End Page

862 / 866

Location

England

Related Subject Headings

  • Treatment Outcome
  • Tetrazoles
  • Nephelometry and Turbidimetry
  • Middle Aged
  • Male
  • Linear Models
  • Hypertension
  • Humans
  • Female
  • Diuretics