Skip to main content
Journal cover image

Association between morning blood pressure surge and cardiovascular remodeling in treated elderly hypertensive subjects.

Publication ,  Journal Article
Yano, Y; Hoshide, S; Inokuchi, T; Kanemaru, Y; Shimada, K; Kario, K
Published in: Am J Hypertens
November 2009

BACKGROUND: It has remained unclear whether or not morning blood pressure (BP) surge (MS) is associated with cardiovascular remodeling in elderly (> or =60 years) hypertensive patients being treated by antihypertensive medications. METHODS: In this cross-sectional study (n = 197; mean 74.6 years; 37% men), we evaluated the association between MS, defined as the highest quartile of morning BP increase from sleep (> or =48 mm Hg; n = 49), and extent of cardiac hypertrophy and carotid artery intima-media thickness (IMT). RESULTS: Although there were no differences in 24-h BP levels and the number of prescribed antihypertensive medications between MS and non-MS group, the use of thiazide diuretics was more frequent in MS group than non-MS group (35% vs. 19%; P < 0.05). The MS group had significantly higher levels of left ventricular mass index (LVMI) and internal-carotid artery (ICA)-IMT than the non-MS group (both P < 0.01), independent of 24-h BP levels, daytime BP variability, the degree of nocturnal BP decline, the plasma low-density lipoprotein levels, and the use of diuretics. Even in subjects with a well-controlled 24-h BP level (<130/80 mm Hg; n = 75), these relationships were similar. A multiple logistic regression analysis showed that the presence of MS was an independent determinant of LV hypertrophy (LVH) (> or =125 g/m(2) in men and > or =110 g/m(2) in women) and assignment to the highest quartile of ICA-IMT (both P < 0.05). CONCLUSIONS: The MS in subjects being treated with antihypertensive medications was significantly associated with cardiovascular remodeling, independently of 24-h BP level, daytime BP variability, and nocturnal BP decline.

Duke Scholars

Published In

Am J Hypertens

DOI

EISSN

1941-7225

Publication Date

November 2009

Volume

22

Issue

11

Start / End Page

1177 / 1182

Location

United States

Related Subject Headings

  • Ventricular Remodeling
  • Ultrasonography
  • Tunica Intima
  • Periodicity
  • Male
  • Hypertrophy, Left Ventricular
  • Hypertension
  • Humans
  • Female
  • Cross-Sectional Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yano, Y., Hoshide, S., Inokuchi, T., Kanemaru, Y., Shimada, K., & Kario, K. (2009). Association between morning blood pressure surge and cardiovascular remodeling in treated elderly hypertensive subjects. Am J Hypertens, 22(11), 1177–1182. https://doi.org/10.1038/ajh.2009.162
Yano, Yuichiro, Satoshi Hoshide, Takashi Inokuchi, Yoshimasa Kanemaru, Kazuyuki Shimada, and Kazuomi Kario. “Association between morning blood pressure surge and cardiovascular remodeling in treated elderly hypertensive subjects.Am J Hypertens 22, no. 11 (November 2009): 1177–82. https://doi.org/10.1038/ajh.2009.162.
Yano Y, Hoshide S, Inokuchi T, Kanemaru Y, Shimada K, Kario K. Association between morning blood pressure surge and cardiovascular remodeling in treated elderly hypertensive subjects. Am J Hypertens. 2009 Nov;22(11):1177–82.
Yano, Yuichiro, et al. “Association between morning blood pressure surge and cardiovascular remodeling in treated elderly hypertensive subjects.Am J Hypertens, vol. 22, no. 11, Nov. 2009, pp. 1177–82. Pubmed, doi:10.1038/ajh.2009.162.
Yano Y, Hoshide S, Inokuchi T, Kanemaru Y, Shimada K, Kario K. Association between morning blood pressure surge and cardiovascular remodeling in treated elderly hypertensive subjects. Am J Hypertens. 2009 Nov;22(11):1177–1182.
Journal cover image

Published In

Am J Hypertens

DOI

EISSN

1941-7225

Publication Date

November 2009

Volume

22

Issue

11

Start / End Page

1177 / 1182

Location

United States

Related Subject Headings

  • Ventricular Remodeling
  • Ultrasonography
  • Tunica Intima
  • Periodicity
  • Male
  • Hypertrophy, Left Ventricular
  • Hypertension
  • Humans
  • Female
  • Cross-Sectional Studies