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Effects of bariatric surgery on retinal microvascular architecture in obese patients.

Publication ,  Journal Article
Viljanen, A; Soinio, M; Cheung, CY-L; Hannukainen, JC; Karlsson, HK; Wong, TY; Hughes, AD; Salminen, P; Nuutila, P; Vesti, E; Tapp, RJ
Published in: Int J Obes (Lond)
September 2019

STUDY AIM: Retinal microvasculature changes reflect systemic small vessel damage from obesity. The impact of bariatric surgery induced weight loss on the microvasculature is relatively unknown. We hypothesized that weight loss following bariatric surgery would be associated with improved structural changes in the retinal microvasculature, reflecting an overall improvement in microvascular health. METHODS: The study included 22 obese subjects scheduled for bariatric surgery (laparoscopic Roux-en-Y gastric bypass or a sleeve gastrectomy) and 15 lean, age-matched controls. Ophthalmic examination, including fundus photography, was performed at baseline and 6-months. Retinal microvasculature caliber was analysed quantitatively using a semi-automated computer program and summarized as central retinal artery equivalent (CRAE) and venular equivalent (CRVE). RESULTS: Mean weight loss at 6 months was 26.1 kg ± 8 kg in the bariatric surgery group. Retinal artery caliber increased (136.0 ± 1.4 to 141.4 ± 1.4 µm, p = 0.013) and venular caliber decreased (202.9 ± 1.9 to 197.3 ± 1.9 µm, p = 0.046) in the bariatric surgery group by 6 months, with no change in arteriolar (136.6 ± 1.1 to 134.5 ± 1.2, p = 0.222) or venular (195.1 ± 2.1 to 193.3 ± 2.2, p = 0.550) caliber in the control group. The arteriolar to venular ratio increased in the bariatric surgery group, with no change in the control group at 6 months. CONCLUSIONS: The findings suggest obesity-related microvascular changes are reversible after bariatric surgery-induced weight loss. The capacity for the retinal microvasculature to improve following bariatric surgery suggests plasticity of the human microvasculature early in the disease course.

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Published In

Int J Obes (Lond)

DOI

EISSN

1476-5497

Publication Date

September 2019

Volume

43

Issue

9

Start / End Page

1675 / 1680

Location

England

Related Subject Headings

  • Weight Loss
  • Treatment Outcome
  • Retinal Vessels
  • Prospective Studies
  • Obesity, Morbid
  • Middle Aged
  • Microvessels
  • Humans
  • Female
  • Endocrinology & Metabolism
 

Citation

APA
Chicago
ICMJE
MLA
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Viljanen, A., Soinio, M., Cheung, C.-L., Hannukainen, J. C., Karlsson, H. K., Wong, T. Y., … Tapp, R. J. (2019). Effects of bariatric surgery on retinal microvascular architecture in obese patients. Int J Obes (Lond), 43(9), 1675–1680. https://doi.org/10.1038/s41366-018-0242-7
Viljanen, Antti, Minna Soinio, Carol Yim-Lui Cheung, Jarna C. Hannukainen, Henry K. Karlsson, Tien Yin Wong, Alun D. Hughes, et al. “Effects of bariatric surgery on retinal microvascular architecture in obese patients.Int J Obes (Lond) 43, no. 9 (September 2019): 1675–80. https://doi.org/10.1038/s41366-018-0242-7.
Viljanen A, Soinio M, Cheung CY-L, Hannukainen JC, Karlsson HK, Wong TY, et al. Effects of bariatric surgery on retinal microvascular architecture in obese patients. Int J Obes (Lond). 2019 Sep;43(9):1675–80.
Viljanen, Antti, et al. “Effects of bariatric surgery on retinal microvascular architecture in obese patients.Int J Obes (Lond), vol. 43, no. 9, Sept. 2019, pp. 1675–80. Pubmed, doi:10.1038/s41366-018-0242-7.
Viljanen A, Soinio M, Cheung CY-L, Hannukainen JC, Karlsson HK, Wong TY, Hughes AD, Salminen P, Nuutila P, Vesti E, Tapp RJ. Effects of bariatric surgery on retinal microvascular architecture in obese patients. Int J Obes (Lond). 2019 Sep;43(9):1675–1680.

Published In

Int J Obes (Lond)

DOI

EISSN

1476-5497

Publication Date

September 2019

Volume

43

Issue

9

Start / End Page

1675 / 1680

Location

England

Related Subject Headings

  • Weight Loss
  • Treatment Outcome
  • Retinal Vessels
  • Prospective Studies
  • Obesity, Morbid
  • Middle Aged
  • Microvessels
  • Humans
  • Female
  • Endocrinology & Metabolism