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Complexity of Delivering Precision Medicine: Opportunities and Challenges.

Publication ,  Journal Article
Davis, AA; McKee, AE; Kibbe, WA; Villaflor, VM
Published in: American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
May 2018

Precision medicine has emerged as a tool to match patients with the appropriate treatment based on the precise molecular features of an individual patient's tumor. Although examples of targeted therapies exist resulting in dramatic improvements in patient outcomes, comprehensive genomic profiling of tumors has also demonstrated the incredible complexity of molecular alterations in tissue and blood. These sequencing methods provide opportunities to study the landscape of tumors at baseline and serially in response to treatment. These tools also serve as important biomarkers to detect resistance to treatment and determine higher likelihood of responding to particular treatments, such as immune checkpoint blockade. Federally funded and publicly available data repositories have emerged as mechanisms for data sharing. In addition, novel clinical trials are emerging to develop new ways of incorporating molecular matched therapy into clinical trials. Various challenges to delivery of precision oncology include understanding the complexity of advanced tumors based on evolving "omics" and treatment resistance. For physicians, determining when and how to incorporate genetic and molecular tools into clinic in a cost-effective manner is critical. Finally, we discuss the importance of well-designed prospective clinical trials, biomarkers such as liquid biopsies, the use of multidisciplinary tumor boards, and data sharing as evidence-based medicine tools to optimally study and deliver precision oncology to our patients.

Duke Scholars

Published In

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting

DOI

EISSN

1548-8756

ISSN

1548-8748

Publication Date

May 2018

Volume

38

Start / End Page

998 / 1007

Related Subject Headings

  • Treatment Outcome
  • Prognosis
  • Precision Medicine
  • Neoplasms
  • Molecular Targeted Therapy
  • Humans
  • High-Throughput Nucleotide Sequencing
  • Clinical Trials as Topic
  • Biomarkers, Tumor
  • 3211 Oncology and carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Davis, A. A., McKee, A. E., Kibbe, W. A., & Villaflor, V. M. (2018). Complexity of Delivering Precision Medicine: Opportunities and Challenges. American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting, 38, 998–1007. https://doi.org/10.1200/edbk_200279
Davis, Andrew A., Amy E. McKee, Warren A. Kibbe, and Victoria M. Villaflor. “Complexity of Delivering Precision Medicine: Opportunities and Challenges.American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting 38 (May 2018): 998–1007. https://doi.org/10.1200/edbk_200279.
Davis AA, McKee AE, Kibbe WA, Villaflor VM. Complexity of Delivering Precision Medicine: Opportunities and Challenges. American Society of Clinical Oncology educational book American Society of Clinical Oncology Annual Meeting. 2018 May;38:998–1007.
Davis, Andrew A., et al. “Complexity of Delivering Precision Medicine: Opportunities and Challenges.American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting, vol. 38, May 2018, pp. 998–1007. Epmc, doi:10.1200/edbk_200279.
Davis AA, McKee AE, Kibbe WA, Villaflor VM. Complexity of Delivering Precision Medicine: Opportunities and Challenges. American Society of Clinical Oncology educational book American Society of Clinical Oncology Annual Meeting. 2018 May;38:998–1007.

Published In

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting

DOI

EISSN

1548-8756

ISSN

1548-8748

Publication Date

May 2018

Volume

38

Start / End Page

998 / 1007

Related Subject Headings

  • Treatment Outcome
  • Prognosis
  • Precision Medicine
  • Neoplasms
  • Molecular Targeted Therapy
  • Humans
  • High-Throughput Nucleotide Sequencing
  • Clinical Trials as Topic
  • Biomarkers, Tumor
  • 3211 Oncology and carcinogenesis