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The African Descent and Glaucoma Evaluation Study (ADAGES): design and baseline data.

Publication ,  Journal Article
Sample, PA; Girkin, CA; Zangwill, LM; Jain, S; Racette, L; Becerra, LM; Weinreb, RN; Medeiros, FA; Wilson, MR; De León-Ortega, J; Tello, C ...
Published in: Archives of ophthalmology (Chicago, Ill. : 1960)
September 2009

To identify factors accounting for differences in glaucoma onset and rate of progression between individuals of African descent and European descent.A prospective, multicenter observational cohort study of 1221 participants of African descent and European descent with no glaucoma (normal), suspected glaucoma, and glaucoma. Six hundred eighty-six patient participants in the African Descent and Glaucoma Evaluation Study will be followed up longitudinally. Four hundred thirty-six participants of European descent from the Diagnostic Innovations in Glaucoma Study (DIGS) were also included. Baseline demographics, visual function (standard automated perimetry, short-wavelength automated perimetry, frequency doubling technology perimetry), optic nerve structure (retina tomography, optical coherence tomography), clinical status, and risk factors were measured.Individuals of African descent had (1) thinner corneas (P < .001) across all diagnostic groups, (2) a higher percentage of reported diabetes mellitus (P < .001) and high blood pressure (P < .001) and a lower percentage of reported heart disease (P = .001), and (3) worse pattern standard deviation for standard automated perimetry fields overall (P = .001) and within normal limits (P = .01) than individuals of European descent. No differences were present for mean intraocular pressure (P = .79).Significant baseline differences were found in a number of clinical findings between persons of African descent compared with European descent. Longitudinal data from the African Descent and Glaucoma Evaluation Study will be important for determining which baseline features are important and predictive for accurate diagnosis and follow-up in this high-risk group. Trial Registration clinicaltrials.gov Identifier: NCT00221923.

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Published In

Archives of ophthalmology (Chicago, Ill. : 1960)

DOI

EISSN

1538-3601

ISSN

0003-9950

Publication Date

September 2009

Volume

127

Issue

9

Start / End Page

1136 / 1145

Related Subject Headings

  • White People
  • Visual Field Tests
  • Tomography, Optical Coherence
  • Risk Factors
  • Retinal Ganglion Cells
  • Prospective Studies
  • Optic Nerve Diseases
  • Optic Disk
  • Ophthalmology & Optometry
  • Ocular Hypertension
 

Citation

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Sample, P. A., Girkin, C. A., Zangwill, L. M., Jain, S., Racette, L., Becerra, L. M., … African Descent and Glaucoma Evaluation Study  Group, . (2009). The African Descent and Glaucoma Evaluation Study (ADAGES): design and baseline data. Archives of Ophthalmology (Chicago, Ill. : 1960), 127(9), 1136–1145. https://doi.org/10.1001/archophthalmol.2009.187
Sample, Pamela A., Christopher A. Girkin, Linda M. Zangwill, Sonia Jain, Lyne Racette, Lida M. Becerra, Robert N. Weinreb, et al. “The African Descent and Glaucoma Evaluation Study (ADAGES): design and baseline data.Archives of Ophthalmology (Chicago, Ill. : 1960) 127, no. 9 (September 2009): 1136–45. https://doi.org/10.1001/archophthalmol.2009.187.
Sample PA, Girkin CA, Zangwill LM, Jain S, Racette L, Becerra LM, et al. The African Descent and Glaucoma Evaluation Study (ADAGES): design and baseline data. Archives of ophthalmology (Chicago, Ill : 1960). 2009 Sep;127(9):1136–45.
Sample, Pamela A., et al. “The African Descent and Glaucoma Evaluation Study (ADAGES): design and baseline data.Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 127, no. 9, Sept. 2009, pp. 1136–45. Epmc, doi:10.1001/archophthalmol.2009.187.
Sample PA, Girkin CA, Zangwill LM, Jain S, Racette L, Becerra LM, Weinreb RN, Medeiros FA, Wilson MR, De León-Ortega J, Tello C, Bowd C, Liebmann JM, African Descent and Glaucoma Evaluation Study  Group. The African Descent and Glaucoma Evaluation Study (ADAGES): design and baseline data. Archives of ophthalmology (Chicago, Ill : 1960). 2009 Sep;127(9):1136–1145.

Published In

Archives of ophthalmology (Chicago, Ill. : 1960)

DOI

EISSN

1538-3601

ISSN

0003-9950

Publication Date

September 2009

Volume

127

Issue

9

Start / End Page

1136 / 1145

Related Subject Headings

  • White People
  • Visual Field Tests
  • Tomography, Optical Coherence
  • Risk Factors
  • Retinal Ganglion Cells
  • Prospective Studies
  • Optic Nerve Diseases
  • Optic Disk
  • Ophthalmology & Optometry
  • Ocular Hypertension