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Alterations in Brain Network Topology and Structural-Functional Connectome Coupling Relate to Cognitive Impairment.

Publication ,  Journal Article
Wang, J; Khosrowabadi, R; Ng, KK; Hong, Z; Chong, JSX; Wang, Y; Chen, C-Y; Hilal, S; Venketasubramanian, N; Wong, TY; Chen, CL-H; Ikram, MK; Zhou, J
Published in: Front Aging Neurosci
2018

According to the network-based neurodegeneration hypothesis, neurodegenerative diseases target specific large-scale neural networks, such as the default mode network, and may propagate along the structural and functional connections within and between these brain networks. Cognitive impairment no dementia (CIND) represents an early prodromal stage but few studies have examined brain topological changes within and between brain structural and functional networks. To this end, we studied the structural networks [diffusion magnetic resonance imaging (MRI)] and functional networks (task-free functional MRI) in CIND (61 mild, 56 moderate) and healthy older adults (97 controls). Structurally, compared with controls, moderate CIND had lower global efficiency, and lower nodal centrality and nodal efficiency in the thalamus, somatomotor network, and higher-order cognitive networks. Mild CIND only had higher nodal degree centrality in dorsal parietal regions. Functional differences were more subtle, with both CIND groups showing lower nodal centrality and efficiency in temporal and somatomotor regions. Importantly, CIND generally had higher structural-functional connectome correlation than controls. The higher structural-functional topological similarity was undesirable as higher correlation was associated with poorer verbal memory, executive function, and visuoconstruction. Our findings highlighted the distinct and progressive changes in brain structural-functional networks at the prodromal stage of neurodegenerative diseases.

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Published In

Front Aging Neurosci

DOI

ISSN

1663-4365

Publication Date

2018

Volume

10

Start / End Page

404

Location

Switzerland

Related Subject Headings

  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1109 Neurosciences
  • 0601 Biochemistry and Cell Biology
 

Citation

APA
Chicago
ICMJE
MLA
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Wang, J., Khosrowabadi, R., Ng, K. K., Hong, Z., Chong, J. S. X., Wang, Y., … Zhou, J. (2018). Alterations in Brain Network Topology and Structural-Functional Connectome Coupling Relate to Cognitive Impairment. Front Aging Neurosci, 10, 404. https://doi.org/10.3389/fnagi.2018.00404
Wang, Juan, Reza Khosrowabadi, Kwun Kei Ng, Zhaoping Hong, Joanna Su Xian Chong, Yijun Wang, Chun-Yin Chen, et al. “Alterations in Brain Network Topology and Structural-Functional Connectome Coupling Relate to Cognitive Impairment.Front Aging Neurosci 10 (2018): 404. https://doi.org/10.3389/fnagi.2018.00404.
Wang J, Khosrowabadi R, Ng KK, Hong Z, Chong JSX, Wang Y, et al. Alterations in Brain Network Topology and Structural-Functional Connectome Coupling Relate to Cognitive Impairment. Front Aging Neurosci. 2018;10:404.
Wang, Juan, et al. “Alterations in Brain Network Topology and Structural-Functional Connectome Coupling Relate to Cognitive Impairment.Front Aging Neurosci, vol. 10, 2018, p. 404. Pubmed, doi:10.3389/fnagi.2018.00404.
Wang J, Khosrowabadi R, Ng KK, Hong Z, Chong JSX, Wang Y, Chen C-Y, Hilal S, Venketasubramanian N, Wong TY, Chen CL-H, Ikram MK, Zhou J. Alterations in Brain Network Topology and Structural-Functional Connectome Coupling Relate to Cognitive Impairment. Front Aging Neurosci. 2018;10:404.

Published In

Front Aging Neurosci

DOI

ISSN

1663-4365

Publication Date

2018

Volume

10

Start / End Page

404

Location

Switzerland

Related Subject Headings

  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1109 Neurosciences
  • 0601 Biochemistry and Cell Biology