Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Utility of fiber-optic bronchoscopy in pulmonary infections among abdominal solid-organ transplant patients: A comprehensive review.

Publication ,  Journal Article
Sakpal, SV; Donahue, S; Crespo, HS; Auvenshine, C; Agarwal, SK; Nazir, J; Santella, RN; Steers, J
Published in: Respir Med
January 2019

Pulmonary infections are frequent complications in abdominal solid-organ transplantation (aSOT) which may threaten patient and allograft survival. Accurate diagnosis and treatment of pulmonary infections in this population can be challenging. Immunosuppressive therapy not only increases the risk of acquiring opportunistic and non-opportunistic infections, but it also impairs the inflammatory responses associated with microbial invasion which in an otherwise normal host produce clinical and radiologic responses that allow for early identification of the offending pathogen. Serologic testing is not a reliable diagnostic modality. Direct microbiological sampling is often necessary to make a definitive diagnosis early in the clinical course to optimize timely, targeted therapy while reducing the risk of developing antimicrobial resistance, and minimize adverse effects of therapy, if any. Fiber-optic bronchoscopy (FOB) with bronchoalveolar lavage (BAL) or transbronchial lung biopsy (TBB) offers such diagnostic advantage and possesses a potential therapeutic value too. This comprehensive review discusses the potential benefits of FOB alongside its risks and complications, indications and contraindications, and techniques. Additionally, the essay highlights FOB's utility and yield specifically with regard to type and timing of infections in aSOT patients.

Duke Scholars

Published In

Respir Med

DOI

EISSN

1532-3064

Publication Date

January 2019

Volume

146

Start / End Page

81 / 86

Location

England

Related Subject Headings

  • Transplant Recipients
  • Respiratory Tract Infections
  • Respiratory System
  • Lung Diseases
  • Inflammation
  • Immunosuppressive Agents
  • Immunocompromised Host
  • Humans
  • Fiber Optic Technology
  • Bronchoscopy
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sakpal, S. V., Donahue, S., Crespo, H. S., Auvenshine, C., Agarwal, S. K., Nazir, J., … Steers, J. (2019). Utility of fiber-optic bronchoscopy in pulmonary infections among abdominal solid-organ transplant patients: A comprehensive review. Respir Med, 146, 81–86. https://doi.org/10.1016/j.rmed.2018.12.002
Sakpal, Sujit Vijay, Steven Donahue, Hector Saucedo Crespo, Christopher Auvenshine, Suresh Kumar Agarwal, Jawad Nazir, Robert N. Santella, and Jeffery Steers. “Utility of fiber-optic bronchoscopy in pulmonary infections among abdominal solid-organ transplant patients: A comprehensive review.Respir Med 146 (January 2019): 81–86. https://doi.org/10.1016/j.rmed.2018.12.002.
Sakpal SV, Donahue S, Crespo HS, Auvenshine C, Agarwal SK, Nazir J, et al. Utility of fiber-optic bronchoscopy in pulmonary infections among abdominal solid-organ transplant patients: A comprehensive review. Respir Med. 2019 Jan;146:81–6.
Sakpal, Sujit Vijay, et al. “Utility of fiber-optic bronchoscopy in pulmonary infections among abdominal solid-organ transplant patients: A comprehensive review.Respir Med, vol. 146, Jan. 2019, pp. 81–86. Pubmed, doi:10.1016/j.rmed.2018.12.002.
Sakpal SV, Donahue S, Crespo HS, Auvenshine C, Agarwal SK, Nazir J, Santella RN, Steers J. Utility of fiber-optic bronchoscopy in pulmonary infections among abdominal solid-organ transplant patients: A comprehensive review. Respir Med. 2019 Jan;146:81–86.
Journal cover image

Published In

Respir Med

DOI

EISSN

1532-3064

Publication Date

January 2019

Volume

146

Start / End Page

81 / 86

Location

England

Related Subject Headings

  • Transplant Recipients
  • Respiratory Tract Infections
  • Respiratory System
  • Lung Diseases
  • Inflammation
  • Immunosuppressive Agents
  • Immunocompromised Host
  • Humans
  • Fiber Optic Technology
  • Bronchoscopy