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Charge Transfer between [4Fe4S] Proteins and DNA Is Unidirectional: Implications for Biomolecular Signaling.

Publication ,  Journal Article
Teo, RD; Rousseau, BJG; Smithwick, ER; Di Felice, R; Beratan, DN; Migliore, A
Published in: Chem
January 2019

Recent experiments suggest that DNA-mediated charge transport might enable signaling between the [4Fe4S] clusters in the C-terminal domains of human DNA primase and polymerase α, as well as the signaling between other replication and repair high-potential [4Fe4S] proteins. Our theoretical study demonstrates that the redox signaling cannot be accomplished exclusively by DNA-mediated charge transport because part of the charge transfer chain has an unfavorable free energy profile. We show that hole or excess electron transfer between a [4Fe4S] cluster and a nucleic acid duplex through a protein medium can occur within microseconds in one direction, while it is kinetically hindered in the opposite direction. We present a set of signaling mechanisms that may occur with the assistance of oxidants or reductants, using the allowed charge transfer processes. These mechanisms would enable the coordinated action of [4Fe4S] proteins on DNA, engaging the [4Fe4S] oxidation state dependence of the protein-DNA binding affinity.

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Published In

Chem

DOI

EISSN

2451-9294

ISSN

2451-9294

Publication Date

January 2019

Volume

5

Issue

1

Start / End Page

122 / 137
 

Citation

APA
Chicago
ICMJE
MLA
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Teo, R. D., Rousseau, B. J. G., Smithwick, E. R., Di Felice, R., Beratan, D. N., & Migliore, A. (2019). Charge Transfer between [4Fe4S] Proteins and DNA Is Unidirectional: Implications for Biomolecular Signaling. Chem, 5(1), 122–137. https://doi.org/10.1016/j.chempr.2018.09.026
Teo, Ruijie D., Benjamin J. G. Rousseau, Elizabeth R. Smithwick, Rosa Di Felice, David N. Beratan, and Agostino Migliore. “Charge Transfer between [4Fe4S] Proteins and DNA Is Unidirectional: Implications for Biomolecular Signaling.Chem 5, no. 1 (January 2019): 122–37. https://doi.org/10.1016/j.chempr.2018.09.026.
Teo RD, Rousseau BJG, Smithwick ER, Di Felice R, Beratan DN, Migliore A. Charge Transfer between [4Fe4S] Proteins and DNA Is Unidirectional: Implications for Biomolecular Signaling. Chem. 2019 Jan;5(1):122–37.
Teo, Ruijie D., et al. “Charge Transfer between [4Fe4S] Proteins and DNA Is Unidirectional: Implications for Biomolecular Signaling.Chem, vol. 5, no. 1, Jan. 2019, pp. 122–37. Epmc, doi:10.1016/j.chempr.2018.09.026.
Teo RD, Rousseau BJG, Smithwick ER, Di Felice R, Beratan DN, Migliore A. Charge Transfer between [4Fe4S] Proteins and DNA Is Unidirectional: Implications for Biomolecular Signaling. Chem. 2019 Jan;5(1):122–137.
Journal cover image

Published In

Chem

DOI

EISSN

2451-9294

ISSN

2451-9294

Publication Date

January 2019

Volume

5

Issue

1

Start / End Page

122 / 137